8E4Q
The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, D, C) | Transient receptor potential cation channel subfamily M member 8 | polymer | 1135 | 131343.4 | 4 | UniProt (U3JD03) Pfam (PF18139) Pfam (PF25508) Pfam (PF00520) UniProt (by SIFTS) (A0A803VFM3) | Ficedula albicollis (Collared flycatcher) | |
| 2 | E, F, G, H (A, B, D, C) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 4 | Chemie (PIO) |
Sequence modifications
A, B, D, C: 1 - 1075 (UniProt: U3JD03)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ala 535 | Phe 558 | engineered mutation |
| Asp 538 | Tyr 561 | engineered mutation |
| Asp 539 | Tyr 562 | engineered mutation |
| Glu 1076 | - | expression tag |
| Met 1077 | - | expression tag |
| Val 1078 | - | expression tag |
| His 1079 | - | expression tag |
| Arg 1080 | - | expression tag |
| Phe 1081 | - | expression tag |
| Arg 1082 | - | expression tag |
| Gln 1083 | - | expression tag |
| Leu 1084 | - | expression tag |
| Asp 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| Lys 1087 | - | expression tag |
| Leu 1088 | - | expression tag |
| Ser 1089 | - | expression tag |
| Asp 1090 | - | expression tag |
| Leu 1091 | - | expression tag |
| Lys 1092 | - | expression tag |
| Gly 1093 | - | expression tag |
| Leu 1094 | - | expression tag |
| Leu 1095 | - | expression tag |
| Lys 1096 | - | expression tag |
| Glu 1097 | - | expression tag |
| Ile 1098 | - | expression tag |
| Ser 1099 | - | expression tag |
| Ser 1100 | - | expression tag |
| Lys 1101 | - | expression tag |
| Ile 1102 | - | expression tag |
| Lys 1103 | - | expression tag |
| Ser 1104 | - | expression tag |
| Asn 1105 | - | expression tag |
| Ser 1106 | - | expression tag |
| Leu 1107 | - | expression tag |
| Glu 1108 | - | expression tag |
| Val 1109 | - | expression tag |
| Leu 1110 | - | expression tag |
| Phe 1111 | - | expression tag |
| Gln 1112 | - | expression tag |
| Gly 1113 | - | expression tag |
| Pro 1114 | - | expression tag |
| Asp 1115 | - | expression tag |
| Tyr 1116 | - | expression tag |
| Lys 1117 | - | expression tag |
| Asp 1118 | - | expression tag |
| Asp 1119 | - | expression tag |
| Asp 1120 | - | expression tag |
| Asp 1121 | - | expression tag |
| Lys 1122 | - | expression tag |
| Ala 1123 | - | expression tag |
| His 1124 | - | expression tag |
| His 1125 | - | expression tag |
| His 1126 | - | expression tag |
| His 1127 | - | expression tag |
| His 1128 | - | expression tag |
| His 1129 | - | expression tag |
| His 1130 | - | expression tag |
| His 1131 | - | expression tag |
| His 1132 | - | expression tag |
| His 1133 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 525373.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2986.3 | |
| All* | Total formula weight | 528359.9 |
