6NR2

Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2

Summary for 6NR2

• Entry DOI: 10.2210/pdb6nr2/pdb
• EMDB information: 0487 0488 0489
• Descriptor: Transient receptor potential cation channel subfamily M member 8, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide (3 entities in total)
• Functional Keywords: ion channel, trp channel, trpm channel, trpm8 channel, cold sensing, lipid sensing, menthol, icilin, ws-12, pi(4, 5)p2, cooling agent, membrane protein, calcium-permeable ion channel, transport protein
• Biological source: Ficedula albicollis (Collared flycatcher); More
• Total number of polymer chains: 4
• Total formula weight: 525659.81

Authors

Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.-Y. (deposition date: 2019-01-22, release date: 2019-02-20, Last modification date: 2019-12-18)

• Primary citation: Yin, Y.,Le, S.C.,Hsu, A.L.,Borgnia, M.J.,Yang, H.,Lee, S.Y.; Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.; Science, 363:-, 2019; PubMed: 30733385; DOI: 10.1126/science.aav9334

Experimental method

ELECTRON MICROSCOPY (4 Å)