6NR2

Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily M member 8	polymer	1135	130078.5	4		Ficedula albicollis (Collared flycatcher)
2	E, G, I, K (A, B, C, D)	(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate	non-polymer		1047.1	4	Chemie (KXP)
3	F, H, J, L (A, B, C, D)	(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide	non-polymer		289.4	4	Chemie (KXS)

Sequence modifications

A, B, C, D: -43 - 50 (PDB: 6NR2)
A, B, C, D: 51 - 109 (PDB: 6NR2)
A, B, C, D: 110 - 1074 (PDB: 6NR2)
A, B, C, D: 1075 - 1133 (PDB: 6NR2)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	520313.8
Non-Polymers*	Number of molecules	8
	Total formula weight	5346.0
All*	Total formula weight	525659.8

*Water molecules are not included.