6NR2

Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transient receptor potential cation channel subfamily M member 8	polymer	1135	130078.5	4		Ficedula albicollis (Collared flycatcher)
2	E, G, I, K (A, B, C, D)	(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate	non-polymer		1047.1	4	Chemie (KXP)
3	F, H, J, L (A, B, C, D)	(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide	non-polymer		289.4	4	Chemie (KXS) PubChem (46174602) PubChem (56929481) PubChem (71311855) PubChem (89463932) PubChem (11266244) PubChem (11358227) PubChem (92981935) PubChem (118387938) PubChem (143039146) PubChem (146027892) PubChem (172866765) PubChem (175567029)

Sequence modifications

A, B, C, D: -43 - 50 (PDB: 6NR2)
A, B, C, D: 51 - 109 (PDB: 6NR2)
A, B, C, D: 110 - 1074 (PDB: 6NR2)
A, B, C, D: 1075 - 1133 (PDB: 6NR2)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	520313.8
Non-Polymers*	Number of molecules	8
	Total formula weight	5346.0
All*	Total formula weight	525659.8

*Water molecules are not included.