8E4M

The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2

Summary for 8E4M

• Entry DOI: 10.2210/pdb8e4m/pdb
• EMDB information: 27892
• Descriptor: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, nonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane, ... (4 entities in total)
• Functional Keywords: trpm8, menthol receptor, cold receptor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 4
• Total formula weight: 530381.41

Authors

Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (deposition date: 2022-08-18, release date: 2022-10-26)

• Primary citation: Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y.; Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.; Science, 378:eadd1268-eadd1268, 2022; PubMed: 36227998; DOI: 10.1126/science.add1268

Experimental method

ELECTRON MICROSCOPY (3.44 Å)