8E4M

The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0006874	biological_process	intracellular calcium ion homeostasis
A	0009266	biological_process	response to temperature stimulus
A	0009409	biological_process	response to cold
A	0009897	cellular_component	external side of plasma membrane
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0044853	cellular_component	plasma membrane raft
A	0045121	cellular_component	membrane raft
A	0050955	biological_process	thermoception
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0006874	biological_process	intracellular calcium ion homeostasis
B	0009266	biological_process	response to temperature stimulus
B	0009409	biological_process	response to cold
B	0009897	cellular_component	external side of plasma membrane
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0044853	cellular_component	plasma membrane raft
B	0045121	cellular_component	membrane raft
B	0050955	biological_process	thermoception
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0006874	biological_process	intracellular calcium ion homeostasis
C	0009266	biological_process	response to temperature stimulus
C	0009409	biological_process	response to cold
C	0009897	cellular_component	external side of plasma membrane
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0044853	cellular_component	plasma membrane raft
C	0045121	cellular_component	membrane raft
C	0050955	biological_process	thermoception
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0120162	biological_process	positive regulation of cold-induced thermogenesis
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0006874	biological_process	intracellular calcium ion homeostasis
D	0009266	biological_process	response to temperature stimulus
D	0009409	biological_process	response to cold
D	0009897	cellular_component	external side of plasma membrane
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0044853	cellular_component	plasma membrane raft
D	0045121	cellular_component	membrane raft
D	0050955	biological_process	thermoception
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0120162	biological_process	positive regulation of cold-induced thermogenesis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE

Chain	Residue	Details
A	PRO734-MET758
B	PRO734-MET758
C	PRO734-MET758
D	PRO734-MET758

---

site_id	SWS_FT_FI2
Number of Residues	216
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ASP759-HIS765
C	HIS818-LYS822
C	GLN891-ARG895
C	GLY913-GLU953
D	ASP759-HIS765
D	HIS818-LYS822
D	GLN891-ARG895
D	GLY913-GLU953
A	HIS818-LYS822
A	GLN891-ARG895
A	GLY913-GLU953
B	ASP759-HIS765
B	HIS818-LYS822
B	GLN891-ARG895
B	GLY913-GLU953
C	ASP759-HIS765

---

site_id	SWS_FT_FI3
Number of Residues	92
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE

Chain	Residue	Details
A	THR766-ASN789
B	THR766-ASN789
C	THR766-ASN789
D	THR766-ASN789

---

site_id	SWS_FT_FI4
Number of Residues	516
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	GLY790-ASP796
D	GLY790-ASP796
D	VAL849-LEU853
D	ILE985-LYS1104
A	VAL849-LEU853
A	ILE985-LYS1104
B	GLY790-ASP796
B	VAL849-LEU853
B	ILE985-LYS1104
C	GLY790-ASP796
C	VAL849-LEU853
C	ILE985-LYS1104

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE

Chain	Residue	Details
A	LEU797-LEU817
B	LEU797-LEU817
C	LEU797-LEU817
D	LEU797-LEU817

---

site_id	SWS_FT_FI6
Number of Residues	100
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE

Chain	Residue	Details
A	SER823-THR848
B	SER823-THR848
C	SER823-THR848
D	SER823-THR848

---

site_id	SWS_FT_FI7
Number of Residues	144
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE

Chain	Residue	Details
A	GLY854-ARG890
B	GLY854-ARG890
C	GLY854-ARG890
D	GLY854-ARG890

---

site_id	SWS_FT_FI8
Number of Residues	64
Details	INTRAMEM: Pore-forming => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE

Chain	Residue	Details
A	TRP896-PHE912
B	TRP896-PHE912
C	TRP896-PHE912
D	TRP896-PHE912

---

site_id	SWS_FT_FI9
Number of Residues	120
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE

Chain	Residue	Details
A	TRP954-GLY984
B	TRP954-GLY984
C	TRP954-GLY984
D	TRP954-GLY984

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRB

Chain	Residue	Details
A	GLU782
A	GLN785
B	GLU782
B	GLN785
C	GLU782
C	GLN785
D	GLU782
D	GLN785

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRB, ECO:0007744|PDB:7WRC

Chain	Residue	Details
A	ASN799
B	ASN799
C	ASN799
D	ASN799

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRC

Chain	Residue	Details
A	ASP802
B	ASP802
C	ASP802
D	ASP802

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:17015441, ECO:0000269|PubMed:19176480

Chain	Residue	Details
A	ASN934
B	ASN934
C	ASN934
D	ASN934

---