8E4P

Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state

Summary for 8E4P

Entry DOI	10.2210/pdb8e4p/pdb
EMDB information	27895
Descriptor	Transient receptor potential cation channel subfamily M member 8, CHOLESTEROL HEMISUCCINATE (2 entities in total)
Functional Keywords	trpm8, menthol receptor, cold receptor, cold sensor, pi(4, 5)p2, cooling agonists, temperature sensing, ion channel, sensory transduction, transient receptor potential ion channel, membrane protein
Biological source	Mus musculus (house mouse)
Total number of polymer chains	4
Total formula weight	532033.96
Authors	Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.-Y. (deposition date: 2022-08-18, release date: 2022-10-26)
Primary citation	Yin, Y.,Zhang, F.,Feng, S.,Butay, K.J.,Borgnia, M.J.,Im, W.,Lee, S.Y. Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378:eadd1268-eadd1268, 2022 Cited by PubMed: 36227998 DOI: 10.1126/science.add1268 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.59 Å)

Structure validation