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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8E4P

Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state

Functional Information from GO Data
ChainGOidnamespacecontents
A0005216molecular_functionmonoatomic ion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0009266biological_processresponse to temperature stimulus
A0009409biological_processresponse to cold
A0009897cellular_componentexternal side of plasma membrane
A0016020cellular_componentmembrane
A0019722biological_processcalcium-mediated signaling
A0034220biological_processmonoatomic ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0044853cellular_componentplasma membrane raft
A0045121cellular_componentmembrane raft
A0050955biological_processthermoception
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0099604molecular_functionligand-gated calcium channel activity
A0120162biological_processpositive regulation of cold-induced thermogenesis
B0005216molecular_functionmonoatomic ion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0009266biological_processresponse to temperature stimulus
B0009409biological_processresponse to cold
B0009897cellular_componentexternal side of plasma membrane
B0016020cellular_componentmembrane
B0019722biological_processcalcium-mediated signaling
B0034220biological_processmonoatomic ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0044853cellular_componentplasma membrane raft
B0045121cellular_componentmembrane raft
B0050955biological_processthermoception
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0099604molecular_functionligand-gated calcium channel activity
B0120162biological_processpositive regulation of cold-induced thermogenesis
C0005216molecular_functionmonoatomic ion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0009266biological_processresponse to temperature stimulus
C0009409biological_processresponse to cold
C0009897cellular_componentexternal side of plasma membrane
C0016020cellular_componentmembrane
C0019722biological_processcalcium-mediated signaling
C0034220biological_processmonoatomic ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0044853cellular_componentplasma membrane raft
C0045121cellular_componentmembrane raft
C0050955biological_processthermoception
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0099604molecular_functionligand-gated calcium channel activity
C0120162biological_processpositive regulation of cold-induced thermogenesis
D0005216molecular_functionmonoatomic ion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0006874biological_processintracellular calcium ion homeostasis
D0009266biological_processresponse to temperature stimulus
D0009409biological_processresponse to cold
D0009897cellular_componentexternal side of plasma membrane
D0016020cellular_componentmembrane
D0019722biological_processcalcium-mediated signaling
D0034220biological_processmonoatomic ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0044853cellular_componentplasma membrane raft
D0045121cellular_componentmembrane raft
D0050955biological_processthermoception
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0099604molecular_functionligand-gated calcium channel activity
D0120162biological_processpositive regulation of cold-induced thermogenesis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues56
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues92
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues40
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues100
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues144
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues64
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues120
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRE","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues140
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7WRC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35662242","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7WRC","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

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PDB entries from 2025-10-22

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