1D1Y
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![BU of 1d1y by Molmil](/molmil-images/mine/1d1y) | BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,3-PBITU (H4B FREE) | Descriptor: | 1,2-ETHANEDIOL, 2-{2-[3-(2-CARBAMIMIDOYLSULFANYL-ETHYL)-PHENYL]-ETHYL}-ISOTHIOUREA, ACETATE ION, ... | Authors: | Raman, C.S, Li, H, Martasek, P, Southan, G.J, Masters, B.S.S, Poulos, T.L. | Deposit date: | 1999-09-21 | Release date: | 2001-07-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. J.Biol.Chem., 276, 2001
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6OCW
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![BU of 6ocw by Molmil](/molmil-images/mine/6ocw) | Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor A85 | Descriptor: | CITRIC ACID, DIMETHYLFORMAMIDE, N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-4-[(2S)-2-methylpiperidin-1-yl]-1,4-dioxobutan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name), ... | Authors: | Hsu, H.C, Li, H. | Deposit date: | 2019-03-25 | Release date: | 2019-10-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Selective Phenylimidazole-Based Inhibitors of theMycobacterium tuberculosisProteasome. J.Med.Chem., 62, 2019
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1N3U
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![BU of 1n3u by Molmil](/molmil-images/mine/1n3u) | Crystal structure of human heme oxygenase 1 (HO-1) in complex with its substrate heme, crystal form B | Descriptor: | CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, heme oxygenase 1 | Authors: | Lad, L, Schuller, D.J, Friedman, J.P, Li, H, Ortiz de Montellano, P.R, Poulos, T.L. | Deposit date: | 2002-10-29 | Release date: | 2002-11-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1 J.Biol.Chem., 278, 2003
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1D1X
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![BU of 1d1x by Molmil](/molmil-images/mine/1d1x) | BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH 1,4-PBITU (H4B BOUND) | Descriptor: | 2-{2-[4-(2-CARBAMIMIDOYLSULFANYL-ETHYL)-PHENYL]-ETHYL}-ISOTHIOUREA, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Raman, C.S, Li, H, Martasek, P, Southan, G.J, Masters, B.S.S, Poulos, T.L. | Deposit date: | 1999-09-21 | Release date: | 2001-07-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. J.Biol.Chem., 276, 2001
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6OCZ
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![BU of 6ocz by Molmil](/molmil-images/mine/6ocz) | Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor A86 | Descriptor: | CITRIC ACID, DIMETHYLFORMAMIDE, N-{(2S)-1-({(2S)-1-[(2,4-difluorobenzyl)amino]-1-oxopropan-2-yl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide (non-preferred name), ... | Authors: | Hsu, H.C, Li, H. | Deposit date: | 2019-03-25 | Release date: | 2019-10-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Selective Phenylimidazole-Based Inhibitors of theMycobacterium tuberculosisProteasome. J.Med.Chem., 62, 2019
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6E14
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![BU of 6e14 by Molmil](/molmil-images/mine/6e14) | Handover mechanism of the growing pilus by the bacterial outer membrane usher FimD | Descriptor: | Chaperone protein FimC, Fimbrial biogenesis outer membrane usher protein, Protein FimF, ... | Authors: | Du, M, Yuan, Z, Yu, H, Henderson, N, Sarowar, S, Zhao, G, Werneburg, G.T, Thanassi, D.G, Li, H. | Deposit date: | 2018-07-09 | Release date: | 2018-10-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Handover mechanism of the growing pilus by the bacterial outer-membrane usher FimD. Nature, 562, 2018
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1Q2O
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![BU of 1q2o by Molmil](/molmil-images/mine/1q2o) | Bovine endothelial nitric oxide synthase N368D mutant heme domain dimer with L-N(omega)-nitroarginine-2,4-L-diaminobutyramide bound | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, CACODYLATE ION, ... | Authors: | Flinspach, M.L, Li, H, Jamal, J, Yang, W, Huang, H, Hah, J.M, Gomez-Vidal, J.A, Litzinger, E.A, Silverman, R.B, Poulos, T.L. | Deposit date: | 2003-07-25 | Release date: | 2004-01-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase. Nat.Struct.Mol.Biol., 11, 2004
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1NI6
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![BU of 1ni6 by Molmil](/molmil-images/mine/1ni6) | Comparisions of the Heme-Free and-Bound Crystal Structures of Human Heme Oxygenase-1 | Descriptor: | CHLORIDE ION, Heme oxygenase 1, alpha-D-glucopyranose-(1-1)-alpha-D-glucopyranose | Authors: | Lad, L, Schuller, D.J, Friedman, J, Li, H, Shimizu, H, Ortiz de Montellano, P.R, Poulos, T.L. | Deposit date: | 2002-12-21 | Release date: | 2003-04-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1 J.Biol.Chem., 278, 2003
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5H3O
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![BU of 5h3o by Molmil](/molmil-images/mine/5h3o) | Structure of a eukaryotic cyclic nucleotide-gated channel | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION | Authors: | Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J. | Deposit date: | 2016-10-26 | Release date: | 2017-01-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature, 542, 2017
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1D1V
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![BU of 1d1v by Molmil](/molmil-images/mine/1d1v) | BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH S-ETHYL-N-PHENYL-ISOTHIOUREA (H4B BOUND) | Descriptor: | 2-ETHYL-1-PHENYL-ISOTHIOUREA, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | Authors: | Raman, C.S, Li, H, Martasek, P, Southan, G.J, Masters, B.S.S, Poulos, T.L. | Deposit date: | 1999-09-21 | Release date: | 2001-07-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. J.Biol.Chem., 276, 2001
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4RR4
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![BU of 4rr4 by Molmil](/molmil-images/mine/4rr4) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367 | Descriptor: | 2-chloro-N-[3-(4-{[(2Z)-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enoyl]amino}phenoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxamide, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Zhu, L, Ren, X, Zhu, J, Li, H. | Deposit date: | 2014-11-06 | Release date: | 2015-11-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367 TO BE PUBLISHED
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4RLI
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![BU of 4rli by Molmil](/molmil-images/mine/4rli) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 | Descriptor: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | Authors: | Zhu, L, Ren, X, Zhu, J, Li, H. | Deposit date: | 2014-10-17 | Release date: | 2015-11-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A048 TO BE PUBLISHED
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3LKZ
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![BU of 3lkz by Molmil](/molmil-images/mine/3lkz) | |
8G6E
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![BU of 8g6e by Molmil](/molmil-images/mine/8g6e) | Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304 | Descriptor: | (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide, Proteasome subunit alpha type, Proteasome subunit alpha type-1, ... | Authors: | Hsu, H.-C, Li, H. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (2.18 Å) | Cite: | Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun, 14, 2023
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8G6F
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![BU of 8g6f by Molmil](/molmil-images/mine/8g6f) | Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs | Descriptor: | (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide, Proteasome endopeptidase complex, Proteasome subunit alpha type-1, ... | Authors: | Hsu, H.-C, Li, H. | Deposit date: | 2023-02-15 | Release date: | 2023-12-20 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (2.58 Å) | Cite: | Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun, 14, 2023
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6ODE
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![BU of 6ode by Molmil](/molmil-images/mine/6ode) | |
7RD6
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![BU of 7rd6 by Molmil](/molmil-images/mine/7rd6) | Structure of the S. cerevisiae P4B ATPase lipid flippase in the E2P state | Descriptor: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Probable phospholipid-transporting ATPase NEO1 | Authors: | Bai, L, Jain, B.K, You, Q, Duan, H.D, Graham, T.R, Li, H. | Deposit date: | 2021-07-09 | Release date: | 2021-09-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Structural basis of the P4B ATPase lipid flippase activity. Nat Commun, 12, 2021
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7RD8
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![BU of 7rd8 by Molmil](/molmil-images/mine/7rd8) | Structure of the S. cerevisiae P4B ATPase lipid flippase in the E1-ATP state | Descriptor: | MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Probable phospholipid-transporting ATPase NEO1 | Authors: | Bai, L, Jain, B.K, You, Q, Duan, H.D, Graham, T.R, Li, H. | Deposit date: | 2021-07-09 | Release date: | 2021-09-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (5.64 Å) | Cite: | Structural basis of the P4B ATPase lipid flippase activity. Nat Commun, 12, 2021
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7RD7
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![BU of 7rd7 by Molmil](/molmil-images/mine/7rd7) | Structure of the S. cerevisiae P4B ATPase lipid flippase in the E2P-transition state | Descriptor: | MAGNESIUM ION, Probable phospholipid-transporting ATPase NEO1, TETRAFLUOROALUMINATE ION | Authors: | Bai, L, Jain, B.K, You, Q, Duan, H.D, Graham, T.R, Li, H. | Deposit date: | 2021-07-09 | Release date: | 2021-09-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Structural basis of the P4B ATPase lipid flippase activity. Nat Commun, 12, 2021
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1HQR
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![BU of 1hqr by Molmil](/molmil-images/mine/1hqr) | CRYSTAL STRUCTURE OF A SUPERANTIGEN BOUND TO THE HIGH-AFFINITY, ZINC-DEPENDENT SITE ON MHC CLASS II | Descriptor: | HLA-DR ALPHA CHAIN, HLA-DR BETA CHAIN, MYELIN BASIC PROTEIN, ... | Authors: | Li, Y, Li, H, Dimasi, N, Schlievert, P, Mariuzza, R. | Deposit date: | 2000-12-19 | Release date: | 2001-01-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II. Immunity, 14, 2001
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7RQH
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![BU of 7rqh by Molmil](/molmil-images/mine/7rqh) | |
6NSE
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![BU of 6nse by Molmil](/molmil-images/mine/6nse) | BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE, H4B-FREE, CANAVANINE COMPLEX | Descriptor: | ACETATE ION, CACODYLIC ACID, GLYCEROL, ... | Authors: | Raman, C.S, Li, H, Martasek, P, Masters, B.S.S, Poulos, T.L. | Deposit date: | 1999-01-13 | Release date: | 2002-05-29 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structures of the Heme Domain of Bovine Endothelial Nitric Oxide Synthase Complexed with Arginine Analogues To be Published
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7MCA
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![BU of 7mca by Molmil](/molmil-images/mine/7mca) | |
8DVF
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![BU of 8dvf by Molmil](/molmil-images/mine/8dvf) | T4 Bacteriophage primosome with single strand DNA, state 1 | Descriptor: | DNA (5'-D(P*GP*GP*CP*TP*G)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA primase, ... | Authors: | Feng, X, Li, H. | Deposit date: | 2022-07-28 | Release date: | 2023-06-14 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
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8DVI
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![BU of 8dvi by Molmil](/molmil-images/mine/8dvi) | T4 bacteriophage primosome with single strand DNA, State 2 | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA (70-MER), DNA primase, ... | Authors: | Feng, X, Li, H. | Deposit date: | 2022-07-29 | Release date: | 2023-06-14 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
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