6ODE
Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor B6
Summary for 6ODE
Entry DOI | 10.2210/pdb6ode/pdb |
Descriptor | Proteasome subunit alpha, Proteasome subunit beta, N-{(2S)-1-({(1S)-1-[5-(2-fluorophenyl)-1H-imidazol-2-yl]ethyl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide, ... (4 entities in total) |
Functional Keywords | mycobacterium tuberculosis, proteasome inhibitor, phenylimidazole, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) More |
Total number of polymer chains | 28 |
Total formula weight | 713663.45 |
Authors | |
Primary citation | Zhan, W.,Hsu, H.C.,Morgan, T.,Ouellette, T.,Burns-Huang, K.,Hara, R.,Wright, A.G.,Imaeda, T.,Okamoto, R.,Sato, K.,Michino, M.,Ramjee, M.,Aso, K.,Meinke, P.T.,Foley, M.,Nathan, C.F.,Li, H.,Lin, G. Selective Phenylimidazole-Based Inhibitors of theMycobacterium tuberculosisProteasome. J.Med.Chem., 62:9246-9253, 2019 Cited by PubMed: 31560200DOI: 10.1021/acs.jmedchem.9b01187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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