6ODE
Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor B6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Proteasome subunit alpha | polymer | 240 | 25972.0 | 14 | UniProt (P9WHU1) Pfam (PF00227) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 20S proteasome alpha subunit, Proteasome core protein PrcA |
| 2 | AA, BA, H, I, J... (H, I, J, K, L...) | Proteasome subunit beta | polymer | 234 | 24445.4 | 14 | UniProt (P9WHT9) Pfam (PF00227) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 20S proteasome beta subunit, Proteasome core protein PrcB |
| 3 | CA, DA, EA, FA, GA... (H, I, J, L, M...) | N-{(2S)-1-({(1S)-1-[5-(2-fluorophenyl)-1H-imidazol-2-yl]ethyl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide | non-polymer | 558.6 | 14 | Chemie (M9G) | |||
| 4 | AB, BB, CB, DB, EB... (K, L, M, N, O...) | water | water | 18.0 | 454 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, O, P, Q, R, S, T, U: 10 - 248 (UniProt: P9WHU1)
| PDB | External Database | Details |
|---|---|---|
| Met 9 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 705843.0 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 7820.4 | |
| All* | Total formula weight | 713663.5 |
