6ODE

Crystal Structure of Mycobacterium tuberculosis Proteasome in Complex with Phenylimidazole-based Inhibitor B6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Proteasome subunit alpha	polymer	240	25972.0	14	UniProt (P9WHU1) Pfam (PF00227) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	20S proteasome alpha subunit, Proteasome core protein PrcA
2	H, I, J, K, L...	Proteasome subunit beta	polymer	234	24445.4	14	UniProt (P9WHT9) Pfam (PF00227) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	20S proteasome beta subunit, Proteasome core protein PrcB
3	H, I, J, L, M...	N-{(2S)-1-({(1S)-1-[5-(2-fluorophenyl)-1H-imidazol-2-yl]ethyl}amino)-1,4-dioxo-4-[(2R)-2-phenylpyrrolidin-1-yl]butan-2-yl}-5-methyl-1,2-oxazole-3-carboxamide	non-polymer		558.6	14	Chemie (M9G)
4		water	water		18.0	454	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, O, P, Q, R, S, T, U: 10 - 248 (UniProt: P9WHU1)

PDB	External Database	Details
Met 9	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	705843.0
Non-Polymers*	Number of molecules	14
	Total formula weight	7820.4
All*	Total formula weight	713663.5

*Water molecules are not included.