8G6E

Structure of the Plasmodium falciparum 20S proteasome complexed with inhibitor TDI-8304

Summary for 8G6E

• Entry DOI: 10.2210/pdb8g6e/pdb
• Related: 8G6F 8UD9
• EMDB information: 29764
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta, (7S,10S,13S)-N-cyclopentyl-10-[2-(morpholin-4-yl)ethyl]-9,12-dioxo-13-(2-oxopyrrolidin-1-yl)-2-oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide, ... (16 entities in total)
• Functional Keywords: proteasome, inhibitor, 20s, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium falciparum NF54; More
• Total number of polymer chains: 28
• Total formula weight: 766218.55

Authors

Hsu, H.-C.,Li, H. (deposition date: 2023-02-15, release date: 2023-12-20, Last modification date: 2024-01-03)

• Primary citation: Hsu, H.C.,Li, D.,Zhan, W.,Ye, J.,Liu, Y.J.,Leung, A.,Qin, J.,Crespo, B.,Gamo, F.J.,Zhang, H.,Cui, L.,Roth, A.,Kirkman, L.A.,Li, H.,Lin, G.; Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors.; Nat Commun, 14:8302-8302, 2023; PubMed: 38097652; DOI: 10.1038/s41467-023-44077-2

Experimental method

ELECTRON MICROSCOPY (2.18 Å)