4RR4

Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367

Summary for 4RR4

DescriptorDihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (6 entities in total)
Functional Keywordsoxidoreductase, fmn binding, mitochondria inner membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion inner membrane ; Single-pass membrane protein  Q02127
Total number of polymer chains1
Total molecular weight43935.93
Authors
Zhu, L.,Ren, X.,Zhu, J.,Li, H. (deposition date: 2014-11-06, release date: 2015-11-25)
Primary citation
Zhu, L.,Ren, X.,Zhu, J.,Li, H.
Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367
TO BE PUBLISHED,
Experimental method
X-RAY DIFFRACTION (2.38 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21330.6%4.7%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4rr4
no rotation
Molmil generated image of 4rr4
rotated about x axis by 90°
Molmil generated image of 4rr4
rotated about y axis by 90°