8G6F
Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs
Summary for 8G6F
Entry DOI | 10.2210/pdb8g6f/pdb |
Related | 8UD9 |
EMDB information | 29765 |
Descriptor | Proteasome subunit alpha type-6, Proteasome subunit beta-3, Proteasome subunit beta-4, ... (16 entities in total) |
Functional Keywords | beta-6 a117d, inhibitor, proteasome, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum Dd2 More |
Total number of polymer chains | 28 |
Total formula weight | 765741.74 |
Authors | Hsu, H.-C.,Li, H. (deposition date: 2023-02-15, release date: 2023-12-20, Last modification date: 2024-01-03) |
Primary citation | Hsu, H.C.,Li, D.,Zhan, W.,Ye, J.,Liu, Y.J.,Leung, A.,Qin, J.,Crespo, B.,Gamo, F.J.,Zhang, H.,Cui, L.,Roth, A.,Kirkman, L.A.,Li, H.,Lin, G. Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun, 14:8302-8302, 2023 Cited by PubMed: 38097652DOI: 10.1038/s41467-023-44077-2 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.58 Å) |
Structure validation
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