8G6F

Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs

Summary for 8G6F

• Entry DOI: 10.2210/pdb8g6f/pdb
• Related: 8UD9
• EMDB information: 29765
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta-3, Proteasome subunit beta-4, ... (16 entities in total)
• Functional Keywords: beta-6 a117d, inhibitor, proteasome, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium falciparum Dd2; More
• Total number of polymer chains: 28
• Total formula weight: 765741.74

Authors

Hsu, H.-C.,Li, H. (deposition date: 2023-02-15, release date: 2023-12-20, Last modification date: 2024-01-03)

• Primary citation: Hsu, H.C.,Li, D.,Zhan, W.,Ye, J.,Liu, Y.J.,Leung, A.,Qin, J.,Crespo, B.,Gamo, F.J.,Zhang, H.,Cui, L.,Roth, A.,Kirkman, L.A.,Li, H.,Lin, G.; Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors.; Nat Commun, 14:8302-8302, 2023; PubMed: 38097652; DOI: 10.1038/s41467-023-44077-2

Experimental method

ELECTRON MICROSCOPY (2.58 Å)