8G6F

Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O	Proteasome subunit alpha type-6	polymer	260	29531.7	2	UniProt (Q8IAR3) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
2	B, P	Proteasome subunit alpha type-2	polymer	235	26556.4	2	UniProt (C6KST3) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
3	C, Q	Proteasome subunit alpha type-3	polymer	246	27977.7	2	UniProt (Q8IDG3) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
4	D, R	Proteasome subunit alpha type-4	polymer	241	27263.3	2	UniProt (Q8IDG2) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
5	E, S	Proteasome subunit alpha type-5	polymer	256	28417.4	2	UniProt (A0A0L7LVZ5) Pfam (PF00227) Pfam (PF10584) UniProt (by SIFTS) (Q8IBI3) In PDB	Plasmodium falciparum Dd2
6	F, T	Proteasome subunit alpha type-1	polymer	254	28871.7	2	UniProt (Q8IK90) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
7	G, U	Proteasome subunit alpha type-3	polymer	252	29324.3	2	UniProt (O77396) Pfam (PF10584) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
8	H, V	Proteasome endopeptidase complex	polymer	252	29143.9	2	UniProt (A0A0L7M1M6) Pfam (PF00227) UniProt (by SIFTS) (Q8I0U7) In PDB	Plasmodium falciparum Dd2
9	I, W	Proteasome subunit beta-2	polymer	229	25104.9	2	UniProt (Q8I6T3) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
10	J, X	Proteasome subunit beta-3	polymer	218	24533.1	2	UniProt (Q8I261) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
11	K, Y	Proteasome subunit beta-4	polymer	195	22889.1	2	UniProt (Q8IKC9) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
12	L, Z	Proteasome subunit beta-5	polymer	211	23620.6	2	UniProt (Q8IJT1) Pfam (PF00227) In PDB	Plasmodium falciparum Dd2
13	M, a	Proteasome subunit beta-6	polymer	240	27345.2	2	UniProt (A0A2I0BU46) Pfam (PF00227) UniProt (by SIFTS) (A0A5K1K7U1) In PDB	Plasmodium falciparum Dd2
14	N, b	Proteasome subunit beta-7	polymer	265	30909.9	2	UniProt (A0A0L7LW03) Pfam (PF00227) UniProt (by SIFTS) (Q7K6A9) In PDB	Plasmodium falciparum Dd2
15	I, L, W, Z	(2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide	non-polymer		690.9	4	Chemie (7F1)
16		water	water		18.0	599	Chemie (HOH)

Sequence modifications

M, a: 1 - 240 (UniProt: A0A2I0BU46)

PDB	External Database	Details
Asp 117	Ala 117	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	762978.3
Non-Polymers*	Number of molecules	4
	Total formula weight	2763.4
All*	Total formula weight	765741.7

*Water molecules are not included.