8G6F
Structure of the Plasmodium falciparum 20S proteasome beta-6 A117D mutant complexed with inhibitor WLW-vs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, O (A, O) | Proteasome subunit alpha type-6 | polymer | 260 | 29531.7 | 2 | UniProt (Q8IAR3) Pfam (PF10584) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 2 | B, P (B, P) | Proteasome subunit alpha type-2 | polymer | 235 | 26556.4 | 2 | UniProt (C6KST3) Pfam (PF10584) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 3 | C, Q (C, Q) | Proteasome subunit alpha type-3 | polymer | 246 | 27977.7 | 2 | UniProt (Q8IDG3) Pfam (PF10584) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 4 | D, R (D, R) | Proteasome subunit alpha type-4 | polymer | 241 | 27263.3 | 2 | UniProt (Q8IDG2) Pfam (PF10584) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 5 | E, S (E, S) | Proteasome subunit alpha type-5 | polymer | 256 | 28417.4 | 2 | UniProt (A0A0L7LVZ5) Pfam (PF00227) Pfam (PF10584) UniProt (by SIFTS) (Q8IBI3) | Plasmodium falciparum Dd2 | |
| 6 | F, T (F, T) | Proteasome subunit alpha type-1 | polymer | 254 | 28871.7 | 2 | UniProt (Q8IK90) Pfam (PF10584) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 7 | G, U (G, U) | Proteasome subunit alpha type-3 | polymer | 252 | 29324.3 | 2 | UniProt (O77396) Pfam (PF10584) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 8 | H, V (H, V) | Proteasome endopeptidase complex | polymer | 252 | 29143.9 | 2 | UniProt (A0A0L7M1M6) Pfam (PF00227) UniProt (by SIFTS) (Q8I0U7) | Plasmodium falciparum Dd2 | |
| 9 | I, W (I, W) | Proteasome subunit beta-2 | polymer | 229 | 25104.9 | 2 | UniProt (Q8I6T3) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 10 | J, X (J, X) | Proteasome subunit beta-3 | polymer | 218 | 24533.1 | 2 | UniProt (Q8I261) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 11 | K, Y (K, Y) | Proteasome subunit beta-4 | polymer | 195 | 22889.1 | 2 | UniProt (Q8IKC9) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 12 | L, Z (L, Z) | Proteasome subunit beta-5 | polymer | 211 | 23620.6 | 2 | UniProt (Q8IJT1) Pfam (PF00227) | Plasmodium falciparum Dd2 | |
| 13 | AA, M (M, a) | Proteasome subunit beta-6 | polymer | 240 | 27345.2 | 2 | UniProt (A0A2I0BU46) Pfam (PF00227) UniProt (by SIFTS) (A0A5K1K7U1) | Plasmodium falciparum Dd2 | |
| 14 | BA, N (N, b) | Proteasome subunit beta-7 | polymer | 265 | 30909.9 | 2 | UniProt (A0A0L7LW03) Pfam (PF00227) UniProt (by SIFTS) (Q7K6A9) | Plasmodium falciparum Dd2 | |
| 15 | CA, DA, EA, FA (I, L, W, Z) | (2S)-N-[(E,2S)-1-(1H-indol-3-yl)-4-methylsulfonyl-but-3-en-2-yl]-2-[[(2S)-3-(1H-indol-3-yl)-2-(2-morpholin-4-ylethanoylamino)propanoyl]amino]-4-methyl-pentanamide | non-polymer | 690.9 | 4 | Chemie (7F1) | |||
| 16 | AB, BB, CB, DB, EB... (U, V, W, X, Y...) | water | water | 18.0 | 599 | Chemie (HOH) |
Sequence modifications
M, a: 1 - 240 (UniProt: A0A2I0BU46)
| PDB | External Database | Details |
|---|---|---|
| Asp 117 | Ala 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 28 |
| Total formula weight | 762978.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2763.4 | |
| All* | Total formula weight | 765741.7 |
