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PDB: 29 results

1QNE
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Crystal structure of the Adenovirus major late promoter TATA box bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2).
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Kim, J.L, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
4XCU
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Crystal Structure of FGFR4 with an Irreversible Inhibitor
Descriptor: Fibroblast growth factor receptor 4, N-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)propanamide, SULFATE ION
Authors:Kim, J.L, Miduturu, C, Hodous, B, Brooijmans, N, Bifulco, N, Guzi, T.
Deposit date:2014-12-18
Release date:2015-04-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.
Cancer Discov, 5, 2015
8D73
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Crystal Structure of EGFR LRTM with compound 7
Descriptor: (3S,4R)-3-fluoro-1-(4-{[4-(methylamino)-1-(propan-2-yl)pyrido[3,4-d]pyridazin-7-yl]amino}pyrimidin-2-yl)piperidin-4-ol, Epidermal growth factor receptor, GLYCEROL
Authors:Kim, J.L.
Deposit date:2022-06-07
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
J.Med.Chem., 65, 2022
8D76
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Crystal Structure of EGFR LRTM with compound 24
Descriptor: (3S,4R)-3-fluoro-1-(4-{[8-{3-[(methanesulfonyl)methyl]azetidin-1-yl}-5-(propan-2-yl)-2,7-naphthyridin-3-yl]amino}pyrimidin-2-yl)-3-methylpiperidin-4-ol, Epidermal growth factor receptor, GLYCEROL
Authors:Kim, J.L.
Deposit date:2022-06-07
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer.
J.Med.Chem., 65, 2022
1A1R
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BU of 1a1r by Molmil
HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX
Descriptor: NS3 PROTEIN, NS4A PROTEIN, ZINC ION
Authors:Kim, J.L, Morgenstern, K.A, Lin, C, Fox, T, Dwyer, M.D, Landro, J.A, Chambers, S.P, Markland, W, Lepre, C.A, O'Malley, E.T, Harbeson, S.L, Rice, C.M, Murcko, M.A, Caron, P.R, Thomson, J.A.
Deposit date:1997-12-15
Release date:1998-06-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
Cell(Cambridge,Mass.), 87, 1996
1A1V
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HEPATITIS C VIRUS NS3 HELICASE DOMAIN COMPLEXED WITH SINGLE STRANDED SDNA
Descriptor: DNA (5'-D(*UP*UP*UP*UP*UP*UP*UP*U)-3'), PROTEIN (NS3 PROTEIN), SULFATE ION
Authors:Kim, J.L, Morgenstern, K.A, Griffith, J.P, Dwyer, M.D, Thomson, J.A, Murcko, M.A, Lin, C, Caron, P.R.
Deposit date:1997-12-17
Release date:1999-01-13
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding.
Structure, 6, 1998
1VTL
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CO-CRYSTAL STRUCTURE OF TBP RECOGNIZING THE MINOR GROOVE OF A TATA ELEMENT
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*C)-3'), TATA BINDING PROTEIN (TBP)
Authors:Kim, J.L, Nikolov, D.B, Burley, S.K.
Deposit date:1993-12-17
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Co-Crystal Structure of TBP Recognizing the Minor Groove of a TATA Element
Nature, 365, 1993
1VTO
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1.9 A RESOLUTION REFINED STRUCTURE OF TBP RECOGNIZING THE MINOR GROOVE OF TATAAAAG
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*C)-3'), TATA BINDING PROTEIN
Authors:Kim, J.L, Burley, S.K.
Deposit date:1996-09-06
Release date:2011-07-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:1.9 A Resolution Refined Structure of TBP Recognizing the Minor Groove of TATAAAAG
Nat.Struct.Biol., 1, 1994
3EFL
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Crystal structure of the VEGFR2 kinase domain in complex with motesanib
Descriptor: N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide, Vascular endothelial growth factor receptor 2
Authors:Kim, J.L, Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H.
Deposit date:2008-09-09
Release date:2009-09-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of Motesanib
To be Published
1QNA
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BU of 1qna by Molmil
Crystal structure of the T(-30) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*TP*TP*TP*AP*AP*AP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*TP*TP*TP*AP*AP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
1QN7
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BU of 1qn7 by Molmil
Crystal structure of the T(-27) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*TP*AP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*TP*AP*TP*AP*TP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
1QN3
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BU of 1qn3 by Molmil
Crystal structure of the C(-25) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*AP*CP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*GP*TP*TP*TP*AP*TP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
1QPC
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BU of 1qpc by Molmil
STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS
Descriptor: 1,2-ETHANEDIOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ...
Authors:Zhu, X, Kim, J.L, Rose, P.E, Stover, D.R, Toledo, L.M, Zhao, H, Morgenstern, K.A.
Deposit date:1999-05-21
Release date:2000-05-24
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.
Structure Fold.Des., 7, 1999
1QN5
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Crystal structure of the G(-26) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*GP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*CP*TP*TP*AP*TP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
3DA6
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BU of 3da6 by Molmil
Crystal Structure of human JNK3 complexed with N-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine
Descriptor: Mitogen-activated protein kinase 10, N-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-1H-benzimidazol-2-amine
Authors:Cee, V.J, Cheng, A.C, Romero, K, Bellon, S, Mohr, C, Whittington, D.A, Bready, J, Caenepeel, S, Coxon, A, Deak, H.L, Hodous, B.L, Kim, J.L, Lin, J, Nguyen, H, Olivieri, P.R, Patel, V.F, Wang, L, Hughes, P, Geuns-Meyer, S.
Deposit date:2008-05-28
Release date:2009-01-06
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase
Bioorg.Med.Chem.Lett., 19, 2009
3BE2
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BU of 3be2 by Molmil
Crystal structure of the VEGFR2 kinase domain in complex with a benzamide inhibitor
Descriptor: N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE, Vascular endothelial growth factor receptor 2
Authors:Whittington, D.A, Kim, J.L, Long, A.M, Gu, Y, Rose, P, Zhao, H.
Deposit date:2007-11-16
Release date:2008-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: design, synthesis, and evaluation.
J.Med.Chem., 51, 2008
1TCO
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BU of 1tco by Molmil
TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
Descriptor: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, CALCIUM ION, FE (III) ION, ...
Authors:Griffith, J.P, Kim, J.L, Kim, E.E, Sintchak, M.D, Thomson, J.A, Fitzgibbon, M.J, Fleming, M.A, Caron, P.R, Hsiao, K, Navia, M.A.
Deposit date:1996-08-21
Release date:1997-02-12
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
Cell(Cambridge,Mass.), 82, 1995
2QU6
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Crystal structure of the VEGFR2 kinase domain in complex with a benzoxazole inhibitor
Descriptor: 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide, SULFATE ION, Vascular endothelial growth factor receptor 2
Authors:Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H.
Deposit date:2007-08-03
Release date:2007-09-25
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50, 2007
2QU5
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Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor
Descriptor: 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide, Vascular endothelial growth factor receptor 2
Authors:Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H.
Deposit date:2007-08-03
Release date:2007-09-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50, 2007
2P2H
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Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor
Descriptor: 4-(2-anilinopyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine, Vascular endothelial growth factor receptor 2
Authors:Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H.
Deposit date:2007-03-07
Release date:2007-03-20
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
J.Med.Chem., 50, 2007
1QNB
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BU of 1qnb by Molmil
Crystal structure of the T(-25) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*AP*TP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*AP*TP*TP*TP*AP*TP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
1QN4
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BU of 1qn4 by Molmil
Crystal structure of the T(-24) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*AP*AP*AP*AP*TP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*AP*TP*TP*TP*TP*AP*TP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-06
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
1QPD
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BU of 1qpd by Molmil
STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS
Descriptor: LCK KINASE, STAUROSPORINE, SULFATE ION
Authors:Zhu, X, Kim, J.L, Rose, P.E, Stover, D.R, Toledo, L.M, Zhao, H, Morgenstern, K.A.
Deposit date:1999-05-24
Release date:2000-05-24
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors.
Structure Fold.Des., 7, 1999
1QN8
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Crystal structure of the T(-28) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*TP*AP*TP*TP*AP*AP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*TP*TP*AP*AP*TP*AP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999
1QNC
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Crystal structure of the A(-31) Adenovirus major late promoter TATA box variant bound to wild-type TBP (Arabidopsis thaliana TBP isoform 2). TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.
Descriptor: DNA (5'-D(*GP*CP*AP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*TP*GP*C)-3'), TRANSCRIPTION INITIATION FACTOR TFIID-1
Authors:Patikoglou, G.A, Kim, J.L, Sun, L, Yang, S.-H, Kodadek, T, Burley, S.K.
Deposit date:1999-10-14
Release date:2000-02-07
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Genes Dev., 13, 1999

 

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