1A1R

HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX

Summary for 1A1R

• Entry DOI: 10.2210/pdb1a1r/pdb
• Descriptor: NS3 PROTEIN, NS4A PROTEIN, ZINC ION, ... (4 entities in total)
• Functional Keywords: viral protein, serine protease, nonstructural proteins, cofactor peptide, helicase
• Biological source: Hepatitis C virus; More
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P27958 P27958
• Total number of polymer chains: 4
• Total formula weight: 47008.85

Authors

Kim, J.L.,Morgenstern, K.A.,Lin, C.,Fox, T.,Dwyer, M.D.,Landro, J.A.,Chambers, S.P.,Markland, W.,Lepre, C.A.,O'Malley, E.T.,Harbeson, S.L.,Rice, C.M.,Murcko, M.A.,Caron, P.R.,Thomson, J.A. (deposition date: 1997-12-15, release date: 1998-06-17, Last modification date: 2024-02-07)

• Primary citation: Kim, J.L.,Morgenstern, K.A.,Lin, C.,Fox, T.,Dwyer, M.D.,Landro, J.A.,Chambers, S.P.,Markland, W.,Lepre, C.A.,O'Malley, E.T.,Harbeson, S.L.,Rice, C.M.,Murcko, M.A.,Caron, P.R.,Thomson, J.A.; Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.; Cell(Cambridge,Mass.), 87:343-355, 1996; PubMed: 8861917; DOI: 10.1016/S0092-8674(00)81351-3

Experimental method

X-RAY DIFFRACTION (2.5 Å)