1TCO

TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)

Summary for 1TCO

Entry DOI	10.2210/pdb1tco/pdb
Descriptor	SERINE/THREONINE PHOSPHATASE B2, FK506-BINDING PROTEIN, ZINC ION, ... (10 entities in total)
Functional Keywords	complex (hydrolase-isomerase), immunosuppressant, complex (hydrolase-isomerase) complex, complex (hydrolase/isomerase)
Biological source	Bos taurus (cattle) More
Cellular location	Nucleus (By similarity): P48452 Cytoplasm: P62942
Total number of polymer chains	3
Total formula weight	75364.00
Authors	Griffith, J.P.,Kim, J.L.,Kim, E.E.,Sintchak, M.D.,Thomson, J.A.,Fitzgibbon, M.J.,Fleming, M.A.,Caron, P.R.,Hsiao, K.,Navia, M.A. (deposition date: 1996-08-21, release date: 1997-02-12, Last modification date: 2011-07-13)
Primary citation	Griffith, J.P.,Kim, J.L.,Kim, E.E.,Sintchak, M.D.,Thomson, J.A.,Fitzgibbon, M.J.,Fleming, M.A.,Caron, P.R.,Hsiao, K.,Navia, M.A. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell(Cambridge,Mass.), 82:507-522, 1995 Cited by PubMed: 7543369 DOI: 10.1016/0092-8674(95)90439-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation