1TCO
TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE PHOSPHATASE B2 | polymer | 375 | 43013.0 | 1 | UniProt (P48452) Pfam (PF00149) | Bos taurus (cattle) | CALCINEURIN A, CAM-PRP CATALYTIC SUBUNIT, CALCINEURIN B, CAM-PRP REGULATORY SUBUNIT |
| 2 | B (B) | SERINE/THREONINE PHOSPHATASE B2 | polymer | 169 | 19191.7 | 1 | UniProt (P63099) Pfam (PF13499) | Bos taurus (cattle) | CALCINEURIN A, CAM-PRP CATALYTIC SUBUNIT, CALCINEURIN B, CAM-PRP REGULATORY SUBUNIT |
| 3 | C (C) | FK506-BINDING PROTEIN | polymer | 107 | 11750.4 | 1 | UniProt (P62942) Pfam (PF00254) UniProt (by SIFTS) (P18203) | Bos taurus (cattle) | FKBP-12, CIS-TRANS ISOMERASE |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) PubChem (29936) | |||
| 6 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 7 | G, H, I, J (B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 8 | K (B) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) PubChem (11005) | |||
| 9 | L (C) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 1 | Chemie (FK5) PubChem (23377000) PubChem (177746942) PubChem (23308325) PubChem (23581796) PubChem (24978521) PubChem (44294761) PubChem (44314852) PubChem (44575549) PubChem (46783859) PubChem (46781577) PubChem (49874294) PubChem (57417278) PubChem (57892354) PubChem (57910335) PubChem (58584114) PubChem (59032416) PubChem (58946030) PubChem (59141120) PubChem (59049316) PubChem (59974193) PubChem (59993548) PubChem (60035606) PubChem (66709866) PubChem (67340654) PubChem (67626881) PubChem (68219140) PubChem (68712665) PubChem (69247758) PubChem (176478128) PubChem (176856280) PubChem (177675132) PubChem (5372) PubChem (64779) PubChem (445643) PubChem (77906388) PubChem (89249909) PubChem (89545901) PubChem (89960652) PubChem (145857191) PubChem (117646237) PubChem (6426916) PubChem (6436007) PubChem (6473866) PubChem (123552884) PubChem (9832283) PubChem (9853905) PubChem (125039862) PubChem (9918805) PubChem (125136698) PubChem (125136697) PubChem (9963169) PubChem (129009965) PubChem (129010422) PubChem (130330191) PubChem (131676819) PubChem (54611630) PubChem (133562888) PubChem (133688365) PubChem (11556866) PubChem (134694629) PubChem (57206900) PubChem (12134936) PubChem (13006299) PubChem (137705868) PubChem (138106951) PubChem (138574020) PubChem (140494820) PubChem (13819070) PubChem (140647114) PubChem (13819074) PubChem (13819069) PubChem (140893615) PubChem (149048732) PubChem (160433486) PubChem (162711219) PubChem (163027397) PubChem (163027399) PubChem (163027400) PubChem (166023667) PubChem (59042420) PubChem (59111253) PubChem (59112447) PubChem (59118415) PubChem (168312998) PubChem (170277719) PubChem (171042252) PubChem (171360199) PubChem (172042935) PubChem (173882479) PubChem (59746606) PubChem (59917266) PubChem (59918741) PubChem (60086106) PubChem (66509027) PubChem (66672804) PubChem (71296869) PubChem (71316759) PubChem (71668407) PubChem (73265325) PubChem (89068341) PubChem (403209) PubChem (124511204) PubChem (439492) PubChem (5353987) PubChem (5472317) PubChem (125039860) PubChem (125039861) PubChem (125136699) PubChem (125136700) PubChem (6536850) PubChem (6610362) PubChem (6912836) PubChem (125182986) PubChem (126687738) PubChem (9940643) PubChem (129606865) PubChem (13819073) PubChem (131668141) PubChem (137546410) PubChem (137546581) PubChem (138574025) PubChem (139032034) PubChem (140652196) PubChem (143265740) PubChem (144640477) PubChem (146323807) PubChem (156417380) PubChem (156528350) PubChem (160433487) PubChem (163027398) PubChem (163027401) PubChem (163027402) PubChem (167413568) PubChem (170997009) PubChem (171122179) PubChem (171137683) PubChem (171156312) PubChem (171322980) PubChem (171329370) PubChem (172634670) PubChem (175667550) | |||
| 10 | M, N, O (A, B, C) | water | water | 18.0 | 710 | Chemie (HOH) |
Sequence modifications
C: 1 - 107 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Ala 18 | Arg 18 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 73955.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1408.9 | |
| All* | Total formula weight | 75364.0 |
