1TCO
TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE PHOSPHATASE B2 | polymer | 375 | 43013.0 | 1 | UniProt (P48452) Pfam (PF00149) | Bos taurus (cattle) | CALCINEURIN A, CAM-PRP CATALYTIC SUBUNIT, CALCINEURIN B, CAM-PRP REGULATORY SUBUNIT |
| 2 | B (B) | SERINE/THREONINE PHOSPHATASE B2 | polymer | 169 | 19191.7 | 1 | UniProt (P63099) Pfam (PF13499) | Bos taurus (cattle) | CALCINEURIN A, CAM-PRP CATALYTIC SUBUNIT, CALCINEURIN B, CAM-PRP REGULATORY SUBUNIT |
| 3 | C (C) | FK506-BINDING PROTEIN | polymer | 107 | 11750.4 | 1 | UniProt (P62942) Pfam (PF00254) UniProt (by SIFTS) (P18203) | Bos taurus (cattle) | FKBP-12, CIS-TRANS ISOMERASE |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 6 | F (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 7 | G, H, I, J (B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 8 | K (B) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 9 | L (C) | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | non-polymer | 804.0 | 1 | Chemie (FK5) | |||
| 10 | M, N, O (A, B, C) | water | water | 18.0 | 710 | Chemie (HOH) |
Sequence modifications
C: 1 - 107 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Ala 18 | Arg 18 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 73955.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1408.9 | |
| All* | Total formula weight | 75364.0 |
