2P2H

Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor

Summary for 2P2H

• Entry DOI: 10.2210/pdb2p2h/pdb
• Related: 2P2I
• Descriptor: Vascular endothelial growth factor receptor 2, 4-(2-anilinopyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine (3 entities in total)
• Functional Keywords: receptor tyrosine kinase, kdr, transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• Total number of polymer chains: 1
• Total formula weight: 36715.05

Authors

Whittington, D.A.,Kim, J.L.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (deposition date: 2007-03-07, release date: 2007-03-20, Last modification date: 2024-02-21)

• Primary citation: Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Bready, J.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Coxon, A.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Hoffman, D.,Johnson, R.E.,Kendall, R.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Tempest, P.,Wang, L.,Whittington, D.A.,Zhao, H.; Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor; J.Med.Chem., 50:611-626, 2007; PubMed: 17253678; DOI: 10.1021/jm061107l

Experimental method

X-RAY DIFFRACTION (1.95 Å)