2P2I
Crystal structure of the VEGFR2 kinase domain in complex with a nicotinamide inhibitor
Summary for 2P2I
Entry DOI | 10.2210/pdb2p2i/pdb |
Related | 2P2H |
Descriptor | Vascular endothelial growth factor receptor 2, N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, kdr, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 2 |
Total formula weight | 73358.11 |
Authors | Whittington, D.A.,Kim, J.L.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (deposition date: 2007-03-07, release date: 2007-03-20, Last modification date: 2024-02-21) |
Primary citation | Hodous, B.L.,Geuns-Meyer, S.D.,Hughes, P.E.,Albrecht, B.K.,Bellon, S.,Bready, J.,Caenepeel, S.,Cee, V.J.,Chaffee, S.C.,Coxon, A.,Emery, M.,Fretland, J.,Gallant, P.,Gu, Y.,Hoffman, D.,Johnson, R.E.,Kendall, R.,Kim, J.L.,Long, A.M.,Morrison, M.,Olivieri, P.R.,Patel, V.F.,Polverino, A.,Rose, P.,Tempest, P.,Wang, L.,Whittington, D.A.,Zhao, H. Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor J.Med.Chem., 50:611-626, 2007 Cited by PubMed: 17253678DOI: 10.1021/jm061107l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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