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4XCU

Crystal Structure of FGFR4 with an Irreversible Inhibitor

Summary for 4XCU
Entry DOI10.2210/pdb4xcu/pdb
DescriptorFibroblast growth factor receptor 4, SULFATE ION, N-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)propanamide, ... (4 entities in total)
Functional Keywordsreceptor tyrosine kinase, hepatocellular carcinoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34474.67
Authors
Kim, J.L.,Miduturu, C.,Hodous, B.,Brooijmans, N.,Bifulco, N.,Guzi, T. (deposition date: 2014-12-18, release date: 2015-04-01, Last modification date: 2018-12-12)
Primary citationHagel, M.,Miduturu, C.,Sheets, M.,Rubin, N.,Weng, W.,Stransky, N.,Bifulco, N.,Kim, J.L.,Hodous, B.,Brooijmans, N.,Shutes, A.,Winter, C.,Lengauer, C.,Kohl, N.E.,Guzi, T.
First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.
Cancer Discov, 5:424-437, 2015
Cited by
PubMed: 25776529
DOI: 10.1158/2159-8290.CD-14-1029
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.71 Å)
Structure validation

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