4XCU

Crystal Structure of FGFR4 with an Irreversible Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fibroblast growth factor receptor 4	polymer	300	33867.2	1	UniProt (P22455) Pfam (PF07714) In PDB	Homo sapiens (Human)	FGFR-4
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	N-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)propanamide	non-polymer		511.4	1	Chemie (40M)
4		water	water		18.0	172	Chemie (HOH)

Sequence modifications

A: 449 - 751 (UniProt: P22455)

PDB	External Database	Details
Met 449	Leu 449	engineered mutation
-	Pro 570	deletion
-	Asp 571	deletion
-	Leu 572	deletion
-	Ser 573	deletion
-	Pro 574	deletion
-	Asp 575	deletion
-	Gly 576	deletion
-	Pro 577	deletion
-	Arg 578	deletion
His 752	-	expression tag
His 753	-	expression tag
His 754	-	expression tag
His 755	-	expression tag
His 756	-	expression tag
His 757	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33867.2
Non-Polymers*	Number of molecules	2
	Total formula weight	607.5
All*	Total formula weight	34474.7

*Water molecules are not included.