3EFL

Crystal structure of the VEGFR2 kinase domain in complex with motesanib

Summary for 3EFL

• Entry DOI: 10.2210/pdb3efl/pdb
• Related: 2P2I
• Descriptor: Vascular endothelial growth factor receptor 2, N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: angiogenesis, motesanib, nicotinamide, receptor tyrosine kinase, transferase
• Biological source: Homo sapiens; More
• Cellular location: Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
• Total number of polymer chains: 2
• Total formula weight: 73312.13

Authors

Kim, J.L.,Whittington, D.A.,Long, A.M.,Rose, P.,Gu, Y.,Zhao, H. (deposition date: 2008-09-09, release date: 2009-09-15, Last modification date: 2024-11-13)

• Primary citation: Tasker, A.S.,Patel, V.F.; Discovery of Motesanib; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)