3EFL

Crystal structure of the VEGFR2 kinase domain in complex with motesanib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Vascular endothelial growth factor receptor 2	polymer	314	36282.6	2	UniProt (P35968) Pfam (PF07714) In PDB	Homo sapiens	VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, CD309 antigen
2	A, B	N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide	non-polymer		373.5	2	Chemie (706)
3		water	water		18.0	142	Chemie (HOH)

Sequence modifications

A, B: 815 - 939 (UniProt: P35968)

PDB	External Database	Details
Ala 817	Cys 817	engineered mutation
Arg 1172	-	expression tag
His 1173	-	expression tag
His 1174	-	expression tag
His 1175	-	expression tag
His 1176	-	expression tag
His 1177	-	expression tag
His 1178	-	expression tag

A, B: 990 - 1171 (UniProt: P35968)

PDB	External Database	Details
Val 990	Glu 990	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72565.2
Non-Polymers*	Number of molecules	2
	Total formula weight	746.9
All*	Total formula weight	73312.1

*Water molecules are not included.