5JDG
 
 | | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 2.5 mM Na+ and 0.1mM Ca2+ | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | | Deposit date: | 2016-04-16 | | Release date: | 2016-05-11 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.407 Å) | | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger.
Nat.Struct.Mol.Biol., 23, 2016
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8GY7
 | | Cryo-EM structure of ACTH-bound melanocortin-2 receptor in complex with MRAP1 and Gs protein | | Descriptor: | CALCIUM ION, Corticotropin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Luo, P, Feng, W.B, Ma, S.S, Dai, A.T, Yuan, Q.N, Wu, K, Yang, D.H, Wang, M.W, Xu, H.E, Jiang, Y. | | Deposit date: | 2022-09-21 | | Release date: | 2023-01-11 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1.
Cell Res., 33, 2023
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5HXH
 | | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with zero Na+ and Ca2+ | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, PENTADECANE, ... | | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | | Deposit date: | 2016-01-30 | | Release date: | 2016-05-11 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.804 Å) | | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger
Nat.Struct.Mol.Biol., 23, 2016
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6NQ0
 | | Cryo-EM structure of human TPC2 channel in the ligand-bound open state | | Descriptor: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | | Authors: | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | Deposit date: | 2019-01-18 | | Release date: | 2019-03-27 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
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6O84
 | | Cryo-EM structure of OTOP3 from xenopus tropicalis | | Descriptor: | LOC100127796 protein,LOC100127796 protein,OTOP3,LOC100127796 protein,LOC100127796 protein | | Authors: | Chen, Q.F, Bai, X.C, Jiang, Y.X. | | Deposit date: | 2019-03-08 | | Release date: | 2019-04-24 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.92 Å) | | Cite: | Structural and functional characterization of an otopetrin family proton channel.
Elife, 8, 2019
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8FY5
 | | Human TMEM175-LAMP1 full-length complex | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | Deposit date: | 2023-01-25 | | Release date: | 2023-06-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
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8FYF
 | | Human TMEM175-LAMP1 transmembrane domain only complex | | Descriptor: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | | Authors: | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | | Deposit date: | 2023-01-26 | | Release date: | 2023-06-28 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
Mol.Cell, 83, 2023
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4HMO
 | | Crystal structure of streptococcus pneumoniae TIGR4 PiaA in complex with Bis-tris propane | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Iron-compound ABC transporter, ... | | Authors: | Cheng, W, Li, Q, Jiang, Y.-L, Chen, Y, Zhou, C.-Z. | | Deposit date: | 2012-10-18 | | Release date: | 2013-09-04 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of Streptococcus pneumoniae PiaA and Its Complex with Ferrichrome Reveal Insights into the Substrate Binding and Release of High Affinity Iron Transporters
Plos One, 8, 2013
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7RH9
 | | Cryo-EM structure of human rod CNGA1/B1 channel in apo state | | Descriptor: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | | Authors: | Xue, J, Han, Y, Jiang, Y. | | Deposit date: | 2021-07-16 | | Release date: | 2021-11-03 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.61 Å) | | Cite: | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.
Neuron, 110, 2022
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3T2M
 | | Crystal Structure of NaK Channel N68D Mutant | | Descriptor: | POTASSIUM ION, Potassium channel protein | | Authors: | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | Deposit date: | 2011-07-22 | | Release date: | 2011-10-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.953 Å) | | Cite: | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3T4Z
 | | Crystal Structure of NaK2K Channel Y55W Mutant | | Descriptor: | POTASSIUM ION, Potassium channel protein | | Authors: | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | Deposit date: | 2011-07-26 | | Release date: | 2011-10-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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1P7M
 | | SOLUTION STRUCTURE AND BASE PERTURBATION STUDIES REVEAL A NOVEL MODE OF ALKYLATED BASE RECOGNITION BY 3-METHYLADENINE DNA GLYCOSYLASE I | | Descriptor: | 3-METHYL-3H-PURIN-6-YLAMINE, DNA-3-methyladenine glycosylase I, ZINC ION | | Authors: | Cao, C, Kwon, K, Jiang, Y.L, Drohat, A.C, Stivers, J.T. | | Deposit date: | 2003-05-02 | | Release date: | 2003-11-25 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I
J.Biol.Chem., 278, 2003
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5HWY
 | | Structural mechanisms of extracellular ion exchange and induced binding-site occlusion in the sodium-calcium exchanger NCX_Mj soaked with 10 mM Na+ and zero Ca2+ | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ACETATE ION, PENTADECANE, ... | | Authors: | Liao, J, Jiang, Y.X, Faraldo-Gomez, J.D. | | Deposit date: | 2016-01-29 | | Release date: | 2016-05-18 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.098 Å) | | Cite: | Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger
Nat.Struct.Mol.Biol., 23, 2016
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7SAS
 | | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2021-09-23 | | Release date: | 2022-03-09 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
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7SAQ
 | | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2021-09-23 | | Release date: | 2022-03-09 | | Last modified: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
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7SAR
 | | Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | | Authors: | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | | Deposit date: | 2021-09-23 | | Release date: | 2022-03-09 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
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1FLZ
 | | URACIL DNA GLYCOSYLASE WITH UAAP | | Descriptor: | URACIL, URACIL-DNA GLYCOSYLASE | | Authors: | Werner, R.M, Jiang, Y.L, Gordley, R.G, Jagadeesh, G.J, Ladner, J.E, Xiao, G, Tordova, M, Gilliland, G.L, Stivers, J.T. | | Deposit date: | 2000-08-15 | | Release date: | 2001-01-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase.
Biochemistry, 39, 2000
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3T4D
 | | Crystal Structure of NaK2K Channel Y55F Mutant | | Descriptor: | POTASSIUM ION, Potassium channel protein | | Authors: | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | Deposit date: | 2011-07-25 | | Release date: | 2011-10-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4MZ4
 | | Discovery of an Irreversible HCV NS5B Polymerase Inhibitor | | Descriptor: | 1-[(2-chloroquinolin-3-yl)methyl]-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION, RNA-directed RNA polymerase | | Authors: | Zeng, Q, Anilkumar, G.N, Rosenblum, S.B, Huang, H.-C, Lesburg, C.A, Jiang, Y, Selyutin, O, Chan, T.-Y, Bennett, F, Chen, K.X, Venkatraman, S, Sannigrahi, M, Velazquez, F, Duca, J.S, Gavalas, S, Huang, Y, Pu, H, Wang, L, Pinto, P, Vibulbhan, B, Agrawal, S, Ferrari, E, Jiang, C.-K, Li, C, Hesk, D, Gesell, J, Sorota, S, Shih, N.-Y, Njoroge, F.G, Kozlowski, J.A. | | Deposit date: | 2013-09-29 | | Release date: | 2013-12-11 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Discovery of an irreversible HCV NS5B polymerase inhibitor.
Bioorg.Med.Chem.Lett., 23, 2013
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3TCU
 | | Crystal Structure of NaK2K Channel D68E Mutant | | Descriptor: | POTASSIUM ION, Potassium channel protein | | Authors: | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | Deposit date: | 2011-08-09 | | Release date: | 2011-10-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4IB4
 | | Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, ... | | Authors: | Wacker, D, Wang, C, Katritch, V, Han, G.W, Huang, X, Vardy, E, McCorvy, J.D, Jiang, Y, Chu, M, Siu, F.Y, Liu, W, Xu, H.E, Cherezov, V, Roth, B.L, Stevens, R.C, GPCR Network (GPCR) | | Deposit date: | 2012-12-07 | | Release date: | 2013-03-13 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural features for functional selectivity at serotonin receptors.
Science, 340, 2013
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3TET
 | | Crystal Structure of NaK2K Channel Y66F Mutant | | Descriptor: | POTASSIUM ION, Potassium channel protein | | Authors: | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | Deposit date: | 2011-08-15 | | Release date: | 2011-10-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3T1C
 | | Crystal Structure of NaK Channel D66Y Mutant | | Descriptor: | POTASSIUM ION, Potassium channel protein | | Authors: | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | Deposit date: | 2011-07-21 | | Release date: | 2011-10-05 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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6JBH
 | | Cryo-EM structure and transport mechanism of a wall teichoic acid ABC transporter | | Descriptor: | TarG, TarH | | Authors: | Chen, L, Hou, W.T, Fan, T, Li, Y.H, Liu, B.H, Jiang, Y.L, Sun, L.F, Chen, Y, Zhou, C.Z. | | Deposit date: | 2019-01-25 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | Cryo-electron Microscopy Structure and Transport Mechanism of a Wall Teichoic Acid ABC Transporter.
Mbio, 11, 2020
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6KKN
 | | Crystal structure of RuBisCO accumulation factor Raf1 from Anabaena sp. PCC 7120 | | Descriptor: | All5250 protein | | Authors: | Xia, L.Y, Jiang, Y.L, Kong, W.W, Chen, Y, Zhou, C.Z. | | Deposit date: | 2019-07-26 | | Release date: | 2020-05-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Molecular basis for the assembly of RuBisCO assisted by the chaperone Raf1.
Nat.Plants, 6, 2020
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