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6NQ0

Cryo-EM structure of human TPC2 channel in the ligand-bound open state

Summary for 6NQ0
Entry DOI10.2210/pdb6nq0/pdb
EMDB information0477 0478 0479
DescriptorTwo pore calcium channel protein 2, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (2 entities in total)
Functional Keywordschannel, lysosome, transport protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight172836.79
Authors
She, J.,Zeng, W.,Guo, J.,Chen, Q.,Bai, X.,Jiang, Y. (deposition date: 2019-01-18, release date: 2019-03-27, Last modification date: 2019-11-20)
Primary citationShe, J.,Zeng, W.,Guo, J.,Chen, Q.,Bai, X.,Jiang, Y.
Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8:-, 2019
Cited by
PubMed: 30860481
DOI: 10.7554/eLife.45222
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.7 Å)
Structure validation

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