1K3M
 
 | | NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES | | 分子名称: | INSULIN | | 著者 | Xu, B, Hua, Q.-X, Nakagawa, S.H, Jia, W, Chu, Y.-C, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2001-10-03 | | 公開日 | 2001-10-17 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A cavity-forming mutation in insulin induces segmental unfolding of a surrounding alpha-helix.
Protein Sci., 11, 2002
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1LKQ
 | | NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-GLY, VAL-A3-GLY, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES | | 分子名称: | INSULIN | | 著者 | Weiss, M.A, Hua, Q.X, Chu, Y.C, Jia, W, Philips, N.F, Wang, R.Y, Katsoyannis, P.G. | | 登録日 | 2002-04-25 | | 公開日 | 2002-05-22 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
J.Biol.Chem., 277, 2002
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2JZQ
 | | Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures | | 分子名称: | Insulin | | 著者 | Hua, Q.X, Nakarawa, S, Jia, W.H, Huang, K, Philips, N.F, Hu, S.Q, Weiss, M.A. | | 登録日 | 2008-01-11 | | 公開日 | 2008-02-26 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
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2K9R
 | | Enhancing the activity of insulin by stereospecific unfolding | | 分子名称: | Insulin | | 著者 | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2008-10-23 | | 公開日 | 2008-11-11 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
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2K91
 | | Enhancing the activity of insulin by stereospecific unfolding | | 分子名称: | Insulin | | 著者 | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2008-09-29 | | 公開日 | 2008-11-18 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
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2KJI
 | | A divergent ins protein in c. elegans structurally resemble insulin and activates the human insulin receptor | | 分子名称: | Probable insulin-like peptide beta-type 5 | | 著者 | Hua, Q.X, Nakarawa, S.H, Wilken, R, Ramos, R.R, Jia, W.H, Bass, J, Weiss, M.A. | | 登録日 | 2009-05-28 | | 公開日 | 2009-06-16 | | 最終更新日 | 2019-09-18 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.
Genes Dev., 17, 2003
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2JMN
 | | NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2006-11-21 | | 公開日 | 2006-12-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
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3ROV
 | | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | | 分子名称: | CHLORIDE ION, Insulin, PHENOL, ... | | 著者 | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | | 登録日 | 2011-04-26 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
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2JUV
 | | AbaA3-DKP-insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2007-09-05 | | 公開日 | 2007-10-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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2KQQ
 | | NMR structure of human insulin mutant gly-b8-d-ala, his-b10-asp, pro-b28-lys, lys-b29-pro, 20 structures | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Hua, Q.X, Wan, Z.L, Zhao, M, Jia, W, Huang, K, Weiss, M.A. | | 登録日 | 2009-11-13 | | 公開日 | 2010-11-24 | | 最終更新日 | 2021-10-13 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog.
To be Published
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2H67
 | | NMR structure of human insulin mutant HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Hua, Q.X, Liu, M, Hu, S.Q, Jia, W, Arvan, P, Weiss, M.A. | | 登録日 | 2006-05-30 | | 公開日 | 2006-07-18 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: Structure and function of an Alab5 analog.
J.Biol.Chem., 281, 2006
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2GYP
 | | Diabetes mellitus due to a frustrated Schellman motif in HNF-1a | | 分子名称: | Hepatocyte nuclear factor 1-alpha | | 著者 | Narayana, N, Phillips, N.B, Hua, Q.X, Jia, W, Weiss, M.A. | | 登録日 | 2006-05-09 | | 公開日 | 2007-03-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Diabetes mellitus due to misfolding of a beta-cell transcription factor: stereospecific frustration of a Schellman motif in HNF-1alpha.
J.Mol.Biol., 362, 2006
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2HH4
 | | NMR structure of human insulin mutant GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | | 分子名称: | insulin A chain, insulin B chain | | 著者 | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | | 登録日 | 2006-06-27 | | 公開日 | 2006-07-18 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
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2HHO
 | | NMR structure of human insulin mutant GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Hua, Q.X, Nakagawa, S, Hu, S.Q, Jia, W, Weiss, M.A. | | 登録日 | 2006-06-28 | | 公開日 | 2006-07-18 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
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2JUU
 | | allo-ThrA3 DKP-insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2007-09-03 | | 公開日 | 2007-10-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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2JUM
 | | ThrA3-DKP-insulin | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | | 登録日 | 2007-08-31 | | 公開日 | 2007-10-16 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
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5XEY
 | | Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus | | 分子名称: | 1-[2,4,6-tris(oxidanyl)phenyl]ethanone, phloretin hydrolase | | 著者 | He, Y.X, Han, J.T, Jia, W.J, Zhang, Z. | | 登録日 | 2017-04-06 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus.
FEBS J., 2019
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5XE5
 | | Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, phloretin hydrolase | | 著者 | He, Y.X, Han, J.T, Jia, W.J, Zhang, Z. | | 登録日 | 2017-04-01 | | 公開日 | 2018-05-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Discovery and structural analysis of a phloretin hydrolase from the opportunistic human pathogen Mycobacterium abscessus.
FEBS J., 2019
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6R9D
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6Y4F
 | | X-ray structure of the Zn-dependent receptor-binding domain of Proteus mirabilis MR/P fimbrial adhesin MrpH | | 分子名称: | Fimbrial adhesin, GLUTAMIC ACID, ZINC ION | | 著者 | Knight, S.D, Ubhayasekera, W, Jiang, W. | | 登録日 | 2020-02-20 | | 公開日 | 2020-08-19 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | MrpH, a new class of metal-binding adhesin, requires zinc to mediate biofilm formation.
Plos Pathog., 16, 2020
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6Y4E
 | | X-ray structure of the Zn-dependent receptor-binding domain of Proteus mirabilis MR/P fimbrial adhesin MrpH | | 分子名称: | Fimbrial adhesin, L(+)-TARTARIC ACID, ZINC ION | | 著者 | Knight, S.D, Ubhayasekera, W, Jiang, W. | | 登録日 | 2020-02-20 | | 公開日 | 2020-08-19 | | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | | 主引用文献 | MrpH, a new class of metal-binding adhesin, requires zinc to mediate biofilm formation.
Plos Pathog., 16, 2020
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1GHD
 | | Crystal structure of the glutaryl-7-aminocephalosporanic acid acylase by mad phasing | | 分子名称: | GLUTARYL-7-AMINOCEPHALOSPORANIC ACID ACYLASE | | 著者 | Ding, Y, Jiang, W, Mao, X, He, H, Zhang, S, Tang, H, Bartlam, M, Ye, S, Jiang, F, Liu, Y, Zhao, G, Rao, Z. | | 登録日 | 2000-12-07 | | 公開日 | 2003-07-08 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Affinity alkylation of the Trp-B4 residue of the beta -subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130.
J.Biol.Chem., 277, 2002
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6LS5
 | | Structure of human liver FBPase complexed with covalent allosteric inhibitor | | 分子名称: | 2-(ethyldisulfanyl)-1,3-benzothiazole, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | | 著者 | Yunyuan, H, Rongrong, S, Yixiang, X, Shuaishuai, N, Yanliang, R, Jian, L, Jian, W. | | 登録日 | 2020-01-17 | | 公開日 | 2020-05-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.031 Å) | | 主引用文献 | Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.
J.Med.Chem., 63, 2020
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2XYZ
 | | De Novo model of Bacteriophage P22 virion coat protein | | 分子名称: | COAT PROTEIN | | 著者 | Chen, D.-H, Baker, M.L, Hryc, C.F, DiMaio, F, Jakana, J, Wu, W, Dougherty, M, Haase-Pettingell, C, Schmid, M.F, Jiang, W, Baker, D, King, J.A, Chiu, W. | | 登録日 | 2010-11-19 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural Basis for Scaffolding-Mediated Assembly and Maturation of a DsDNA Virus.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2XYY
 | | De Novo model of Bacteriophage P22 procapsid coat protein | | 分子名称: | COAT PROTEIN | | 著者 | Chen, D.-H, Baker, M.L, Hryc, C.F, DiMaio, F, Jakana, J, Wu, W, Dougherty, M, Haase-Pettingell, C, Schmid, M.F, Jiang, W, Baker, D, King, J.A, Chiu, W. | | 登録日 | 2010-11-19 | | 公開日 | 2011-02-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural Basis for Scaffolding-Mediated Assembly and Maturation of a DsDNA Virus.
Proc.Natl.Acad.Sci.USA, 108, 2011
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