2NBP
 
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8CR6
 | | mouse Interleukin-12 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit alpha, Interleukin-12 subunit beta, ... | | Authors: | Merceron, R, Felix, J, Lambert, E, Bloch, Y, Savvides, S.N. | | Deposit date: | 2023-03-07 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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5FRH
 | | Solution structure of oxidised RsrA | | Descriptor: | ANTI-SIGMA FACTOR RSRA | | Authors: | Zdanowski, K, Pecqueur, L, Werner, J, Potts, J.R, Kleanthous, C. | | Deposit date: | 2015-12-17 | | Release date: | 2016-08-03 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | The Anti-Sigma Factor Rsra Responds to Oxidative Stress by Reburying its Hydrophobic Core.
Nat.Commun., 7, 2016
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8CR5
 | | Murine Interleukin-12 receptor beta 1 domain 1 in complex with murine Interleukin-12 beta. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, Interleukin-12 subunit beta, ... | | Authors: | Merceron, R, Bloch, Y, Felix, J, Savvides, S.N. | | Deposit date: | 2023-03-07 | | Release date: | 2024-02-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.
Nat.Struct.Mol.Biol., 31, 2024
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1XHX
 | | Phi29 DNA Polymerase, orthorhombic crystal form | | Descriptor: | DNA polymerase, MAGNESIUM ION, SULFATE ION | | Authors: | Kamtekar, S, Berman, A.J, Wang, J, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A. | | Deposit date: | 2004-09-21 | | Release date: | 2004-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage phi29
Mol.Cell, 16, 2004
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4I2Y
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8JQR
 | | Structure of human TRPV1 in complex with antagonist | | Descriptor: | 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile, CHOLESTEROL, Transient receptor potential cation channel subfamily V member 1,PreScission Site,Green fluorescent protein | | Authors: | Fan, J, Lei, X. | | Deposit date: | 2023-06-14 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Structural basis of TRPV1 inhibition by SAF312 and cholesterol
Nat Commun, 15, 2024
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8KCO
 | | Cryo-EM structure of human gamma-secretase in complex with RO4929097 | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Guo, X, Li, H, Kai, U, Yan, C, Lei, J, Zhou, R, Shi, Y. | | Deposit date: | 2023-08-08 | | Release date: | 2024-08-14 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
To Be Published
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4HKA
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8CLA
 | | Z-SBTubA4 photoswitch bound to tubulin-DARPin D1 complex | | Descriptor: | 2-methoxy-5-[2-(5,6,7-trimethoxy-1,3-benzothiazol-2-yl)ethyl]phenol, CALCIUM ION, Designed Ankyrin Repeat Protein (DARPIN) D1, ... | | Authors: | Wranik, M, Bertrand, Q, Kepa, M.W, Weinert, T, Steinmetz, M, Standfuss, J. | | Deposit date: | 2023-02-16 | | Release date: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free electron lasers
To Be Published
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1WAQ
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1W4Y
 | | Ferrous horseradish peroxidase C1A in complex with carbon monoxide | | Descriptor: | CALCIUM ION, CARBON MONOXIDE, HORSERADISH PEROXIDASE C1A, ... | | Authors: | Carlsson, G.H, Nicholls, P, Svistunenko, D, Berglund, G.I, Hajdu, J. | | Deposit date: | 2004-08-03 | | Release date: | 2005-01-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Complexes of Horseradish Peroxidase with Formate, Acetate, and Carbon Monoxide
Biochemistry, 44, 2005
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1W97
 | | cyto-EpsL: the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae | | Descriptor: | TYPE II SECRETION SYSTEM PROTEIN L | | Authors: | Abendroth, J, Bagdasarian, M, Sansdkvist, M, Hol, W.G.J. | | Deposit date: | 2004-10-06 | | Release date: | 2004-11-30 | | Last modified: | 2019-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The Structure of the Cytoplasmic Domain of Epsl, an Inner Membrane Component of the Type II Secretion System of Vibrio Cholerae: An Unusual Member of the Actin-Like ATPase Superfamily
J.Mol.Biol., 344, 2004
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8CQT
 | | Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_1316) | | Descriptor: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, Putative NADH dehydrogenase/NAD(P)H nitroreductase | | Authors: | Blaha, J, Adam, L, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M. | | Deposit date: | 2023-03-07 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
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8CQU
 | | Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_1680) | | Descriptor: | CITRIC ACID, Putative NADH dehydrogenase/NAD(P)H nitroreductase, TERTIARY-BUTYL ALCOHOL | | Authors: | Blaha, J, Adam, L, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M. | | Deposit date: | 2023-03-07 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
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8CQS
 | | Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_0217) | | Descriptor: | FLAVIN MONONUCLEOTIDE, Nitroreductase-like protein, PHOSPHATE ION | | Authors: | Blaha, J, Gratzl, S, Mortensen, S.A, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M. | | Deposit date: | 2023-03-07 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
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8CQV
 | | Flavin mononucleotide-dependent nitroreductase B.thetaiotaomicron (BT_3392) | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Blaha, J, Adam, L, Beckham, K.S.H, Chojnowski, G, Wilmanns, M, Zimmermann, M. | | Deposit date: | 2023-03-07 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural insights into the diversity of nitroreductase enzymes in Bacteroides thetaiotaomicron
To Be Published
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5FXR
 | | IGFR-1R complex with a pyrimidine inhibitor. | | Descriptor: | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR | | Authors: | Degorce, S, Boyd, S, Curwen, J, Ducray, R, Halsall, C, Jones, C, Lach, F, Lenz, E, Pass, M, Pass, S, Trigwell, C, Norman, R, Phillips, C. | | Deposit date: | 2016-03-02 | | Release date: | 2016-10-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R).
J. Med. Chem., 59, 2016
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1VZB
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8C67
 | | Crystal structure of Ab25 Fab | | Descriptor: | antibody 25 heavy chain, antibody 25 light chain | | Authors: | Nyblom, M, Izadi, A, Tang, D, Bahnan, W, Happonen, L, Malmstroem, J, Shannon, O, Malmstroem, L, Nordenfelt, P. | | Deposit date: | 2023-01-11 | | Release date: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Engineering of IgG1 hinge to the flexible IgG3 hinge enhances immune defense against streptococci
To Be Published
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8CPL
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1AVR
 | | CRYSTAL AND MOLECULAR STRUCTURE OF HUMAN ANNEXIN V AFTER REFINEMENT. IMPLICATIONS FOR STRUCTURE, MEMBRANE BINDING AND ION CHANNEL FORMATION OF THE ANNEXIN FAMILY OF PROTEINS | | Descriptor: | ANNEXIN V, CALCIUM ION, SULFATE ION | | Authors: | Huber, R, Berendes, R, Burger, A, Schneider, M, Karshikov, A, Luecke, H, Roemisch, J, Paques, E. | | Deposit date: | 1991-10-17 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins.
J.Mol.Biol., 223, 1992
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5XP3
 | | Crystal structure of apo T2R-TTL | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GLYCEROL, ... | | Authors: | Wang, Y, Yang, J, Wang, T, Chen, L. | | Deposit date: | 2017-05-31 | | Release date: | 2017-10-25 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin.
J. Biol. Chem., 2018
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1K6I
 | | Crystal structure of Nmra, a negative transcriptional regulator (Trigonal form) | | Descriptor: | CHLORIDE ION, NmrA | | Authors: | Stammers, D.K, Ren, J, Leslie, K, Nichols, C.E, Lamb, H.K, Cocklin, S, Dodds, A, Hawkins, A.R. | | Deposit date: | 2001-10-16 | | Release date: | 2001-12-05 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases.
EMBO J., 20, 2001
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8C4X
 | | PAM Protease | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | | Authors: | Nomme, J, Gavalda, S, Cioci, G, Guicherd, M, Marty, A, Duquesne, S, Ben Khaled, M. | | Deposit date: | 2023-01-05 | | Release date: | 2024-07-17 | | Last modified: | 2024-08-07 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | An engineered enzyme embedded into PLA to make self-biodegradable plastic.
Nature, 631, 2024
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