2NBP

Solution structure of the T119M variant of transthyretin in its monomeric state

Summary for 2NBP

Entry DOI	10.2210/pdb2nbp/pdb
Related	2NBO
NMR Information	BMRB: 25987
Descriptor	Transthyretin (1 entity in total)
Functional Keywords	transthyretin, amyloid, aggregation, monomer, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	1
Total formula weight	13809.51
Authors	Kim, J.,Oroz, J.,Zweckstetter, M. (deposition date: 2016-03-09, release date: 2017-05-10, Last modification date: 2024-05-15)
Primary citation	Kim, J.H.,Oroz, J.,Zweckstetter, M. Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation. Angew. Chem. Int. Ed. Engl., 55:16168-16171, 2016 Cited by PubMed Abstract: Mutations in the protein transthyretin can cause as well as protect individuals from transthyretin amyloidosis, an incurable fatal inherited disease. Little is known, however, about the structural basis of pathogenic and clinically protective transthyretin mutants. Here we determined the solution structure of a transthyretin monomer that carries the clinically important T119M mutation. The structure displays a non-native arrangement that is distinct from all known structures of transthyretin and highlights the importance of high-resolution studies in solution for understanding molecular processes that lead to amyloid diseases. PubMed: 27885756 DOI: 10.1002/anie.201608516 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation