8JDR
 
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxy-3-methyl-valeric acid | | Descriptor: | (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDU
 | | Crystal structure of mLDHD in complex with 2-ketovaleric acid | | Descriptor: | 2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDY
 | | Crystal structure of mLDHD in complex with 2-ketoisocaproic acid | | Descriptor: | 2-OXO-4-METHYLPENTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.59 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDD
 | | Crystal structure of H405A mLDHD in apo form | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDZ
 | | Crystal structure of mLDHD in complex with 2-keto-3-methylvaleric acid | | Descriptor: | (3S)-3-methyl-2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8PWZ
 | | Crystal Structure of (3R)-hydroxyacyl-ACP dehydratase HadBD from Mycobacterium tuberculosis | | Descriptor: | (3R)-hydroxyacyl-ACP dehydratase subunit HadB, UPF0336 protein Rv0504c | | Authors: | Rima, J, Grimoire, Y, Bories, P, Bardou, F, Quemard, A, Bon, C, Mourey, L, Tranier, S. | | Deposit date: | 2023-07-22 | | Release date: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.00196719 Å) | | Cite: | HadBD dehydratase from Mycobacterium tuberculosis fatty acid synthase type II: A singular structure for a unique function.
Protein Sci., 33, 2024
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8JDF
 | | Crystal structure of H405A mLDHD in complex with D-lactate | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDX
 | | Crystal structure of mLDHD in complex with 2-ketoisovaleric acid | | Descriptor: | 3-METHYL-2-OXOBUTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDE
 | | Crystal structure of mLDHD in complex with D-lactate | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LACTIC ACID, MANGANESE (II) ION, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-13 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.729 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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8JDO
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyhexanoic acid | | Descriptor: | (2R)-2-hydroxyhexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.72 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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3JBM
 | | Electron cryo-microscopy of a virus-like particle of orange-spotted grouper nervous necrosis virus | | Descriptor: | virus-like particle of orange-spotted grouper nervous necrosis virus | | Authors: | Xie, J, Li, K, Gao, Y, Huang, R, Lai, Y, Shi, Y, Yang, S, Zhu, G, Zhang, Q, He, J. | | Deposit date: | 2015-09-06 | | Release date: | 2016-10-19 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural analysis and insertion study reveal the ideal sites for surface displaying foreign peptides on a betanodavirus-like particle
Vet. Res., 47, 2016
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8JDP
 | | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisovaleric acid | | Descriptor: | DEAMINOHYDROXYVALINE, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | | Authors: | Jin, S, Chen, X, Yang, J, Ding, J. | | Deposit date: | 2023-05-15 | | Release date: | 2023-10-18 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Nat Commun, 14, 2023
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6LPT
 | | Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-lactate (D-LAC) | | Descriptor: | D-2-hydroxyglutarate dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Yang, J, Zhu, H, Ding, J. | | Deposit date: | 2020-01-12 | | Release date: | 2021-01-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.621 Å) | | Cite: | Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations.
Cell Discov, 7, 2021
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6G9I
 | | Crystal structure of Ebolavirus glycoprotein in complex with clomipramine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, Envelope glycoprotein,Envelope glycoprotein, ... | | Authors: | Zhao, Y, Ren, J, Fry, E.E, Xiao, J, Townsend, A.R, Stuart, D.I. | | Deposit date: | 2018-04-10 | | Release date: | 2018-05-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.
J. Med. Chem., 61, 2018
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6HJH
 | | Myxococcus xanthus MglA bound to GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Mutual gliding-motility protein MglA | | Authors: | Varela, P.F, Cherfils, J. | | Deposit date: | 2018-09-03 | | Release date: | 2019-12-04 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | MglA functions as a three-state GTPase to control movement reversals of Myxococcus xanthus.
Nat Commun, 10, 2019
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3KAQ
 | | Flavodoxin from D. desulfuricans (semireduced form) | | Descriptor: | FLAVIN MONONUCLEOTIDE, Flavodoxin | | Authors: | Romero, A, Caldeira, J, LeGall, J, Moura, I, Moura, J.J.G, Romao, M.J. | | Deposit date: | 2009-10-19 | | Release date: | 2009-11-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Crystal structure of flavodoxin from Desulfovibrio desulfuricans ATCC 27774 in two oxidation states.
Eur.J.Biochem., 239, 1996
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8S99
 | | Crystal structure of the TYK2 pseudokinase domain in complex with compound 11 | | Descriptor: | (8S)-N-[(1R,2S)-2-fluorocyclopropyl]-5-{[(1M,2'M)-3'-fluoro-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. | | Deposit date: | 2023-03-27 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J.Med.Chem., 66, 2023
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5BU4
 | | RIBONUCLEASE T1 COMPLEX WITH 2'GMP | | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | | Authors: | Loris, R, Devos, S, Langhorst, U, Decanniere, K, Bouckaert, J, Maes, D, Transue, T.R, Steyaert, J. | | Deposit date: | 1998-09-15 | | Release date: | 1998-09-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Conserved water molecules in a large family of microbial ribonucleases.
Proteins, 36, 1999
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8S9A
 | | Crystal structure of the TYK2 pseudokinase domain in complex with TAK-279 | | Descriptor: | (8S)-N-[(1R,2R)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1P,2'P)-2-oxo-2H-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide, 1,2-ETHANEDIOL, ACETATE ION, ... | | Authors: | Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. | | Deposit date: | 2023-03-27 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J.Med.Chem., 66, 2023
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3B6P
 | | Structure of TREX1 in complex with a nucleotide and inhibitor ions (sodium and zinc) | | Descriptor: | SODIUM ION, THYMIDINE-5'-PHOSPHATE, Three prime repair exonuclease 1, ... | | Authors: | Brucet, M, Querol-Audi, J, Fita, I, Celada, A. | | Deposit date: | 2007-10-29 | | Release date: | 2008-09-23 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.
Protein Sci., 17, 2008
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8S98
 | | Crystal structure of the TYK2 pseudokinase domain in complex with compound 8 | | Descriptor: | (8S)-N-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | | Authors: | Toms, A.V, Leit, S, Greenwood, J.R, Carriero, S, Mondal, S, Abel, R, Ashwell, M, Blanchette, H, Boyles, N, Cartwright, M, Collis, A, Feng, S, Ghanakota, P, Harriman, G.C, Hosagrahara, V, Kaila, N, Kapeller, R, Rafi, S, Romero, D.L, Tarantino, P, Timaniya, J, Wester, R.T, Westlin, W, Srivastava, B, Miao, W, Tummino, P, McElwee, J.J, Edmondson, S.D, Massee, C.E. | | Deposit date: | 2023-03-27 | | Release date: | 2023-07-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.
J.Med.Chem., 66, 2023
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5BR8
 | | Ambient-temperature crystal structure of 30S ribosomal subunit from Thermus thermophilus in complex with paromomycin | | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | Authors: | Sierra, R.G, Gati, C, Laksmono, H, Dao, E.H, Gul, S, Fuller, F, Kern, J, Chatterjee, R, Ibrahim, M, Brewster, A, Young, I.D, Michels-Clark, T, Aquila, A, Mengning, L, Hunter, M.S, Koglin, J.E, Boutet, S, Junco, E.A, Hayes, B, Bogan, M.J, Hampton, C.Y, Puglisi, E.V, Sauter, N.K, Stan, C.A, Zouni, A, Yano, J, Yachandra, V.K, Soltis, S.M, Puglisi, J.D, DeMirci, H. | | Deposit date: | 2015-05-29 | | Release date: | 2015-11-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Ambient-temperature crystal structure of 30S ribosomal subunit from Thermus thermophilus in complex with paromomycin
To Be Published
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8S9B
 | | Cryo-EM structure of Nav1.7 with LCM | | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Fan, X, Huang, J, Yan, N. | | Deposit date: | 2023-03-27 | | Release date: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural mapping of Na v 1.7 antagonists.
Nat Commun, 14, 2023
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3JBL
 | | Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization | | Descriptor: | NLR family CARD domain-containing protein 4 | | Authors: | Zhang, L, Chen, S, Ruan, J, Wu, J, Tong, A.B, Yin, Q, Li, Y, David, L, Lu, A, Wang, W.L, Marks, C, Ouyang, Q, Zhang, X, Mao, Y, Wu, H. | | Deposit date: | 2015-09-05 | | Release date: | 2015-10-21 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350, 2015
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5XOB
 | | Crystal structure of apo TiaS (tRNAIle2 agmatidine synthetase) | | Descriptor: | MAGNESIUM ION, ZINC ION, tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS | | Authors: | Dong, J. | | Deposit date: | 2017-05-27 | | Release date: | 2018-08-29 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon.
J. Mol. Biol., 430, 2018
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