3JBL

Cryo-EM Structure of the Activated NAIP2/NLRC4 Inflammasome Reveals Nucleated Polymerization

Summary for 3JBL

EMDB information6458 6459 6460
DescriptorNLR family CARD domain-containing protein 4 (1 entity in total)
Functional Keywordsinflammasome, nlrc4, naip2, immune system
Biological sourceMus musculus (mouse)
Total number of polymer chains11
Total molecular weight1168636.82
Authors
Zhang, L.,Chen, S.,Ruan, J.,Wu, J.,Tong, A.B.,Yin, Q.,Li, Y.,David, L.,Lu, A.,Wang, W.L.,Marks, C.,Ouyang, Q.,Zhang, X.,Mao, Y.,Wu, H. (deposition date: 2015-09-05, release date: 2015-10-21, Last modification date: 2018-07-18)
Primary citation
Zhang, L.,Chen, S.,Ruan, J.,Wu, J.,Tong, A.B.,Yin, Q.,Li, Y.,David, L.,Lu, A.,Wang, W.L.,Marks, C.,Ouyang, Q.,Zhang, X.,Mao, Y.,Wu, H.
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
Science, 350:404-409, 2015
PubMed: 26449474 (PDB entries with the same primary citation)
DOI: 10.1126/science.aac5789
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (4.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers291.8%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation report