3B6P

Structure of TREX1 in complex with a nucleotide and inhibitor ions (sodium and zinc)

Summary for 3B6P

Entry DOI	10.2210/pdb3b6p/pdb
Related	1Y97 2IOC 2O4G 2O4I 2OA8 3B6O
Descriptor	Three prime repair exonuclease 1, ZINC ION, SODIUM ION, ... (5 entities in total)
Functional Keywords	trex1, dedd, exonuclease, dnaq, sodium, zinc, catalysis, inhibition, deoxy-thimidine monophosphate (dtmp), dna damage, dna repair, hydrolase, magnesium, nucleus, phosphorylation
Biological source	Mus musculus (Mouse)
Cellular location	Nucleus (By similarity): Q91XB0
Total number of polymer chains	4
Total formula weight	110334.47
Authors	Brucet, M.,Querol-Audi, J.,Fita, I.,Celada, A. (deposition date: 2007-10-29, release date: 2008-09-23, Last modification date: 2023-08-30)
Primary citation	Brucet, M.,Querol-Audi, J.,Bertlik, K.,Lloberas, J.,Fita, I.,Celada, A. Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. Protein Sci., 17:2059-2069, 2008 Cited by PubMed: 18780819 DOI: 10.1110/ps.036426.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation