6LPT

Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-lactate (D-LAC)

Summary for 6LPT

Entry DOI	10.2210/pdb6lpt/pdb
Descriptor	D-2-hydroxyglutarate dehydrogenase, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ZINC ION, ... (5 entities in total)
Functional Keywords	dehydrogenase, flavoprotein, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	106547.82
Authors	Yang, J.,Zhu, H.,Ding, J. (deposition date: 2020-01-12, release date: 2021-01-13, Last modification date: 2023-11-29)
Primary citation	Yang, J.,Zhu, H.,Zhang, T.,Ding, J. Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Cell Discov, 7:3-3, 2021 Cited by PubMed: 33431826 DOI: 10.1038/s41421-020-00227-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.621 Å)

Structure validation