7MU2
| Crystal Structure of WIPI2 in complex with W2IR of ATG16L1 | Descriptor: | Autophagy-related protein 16-1, WD repeat domain phosphoinositide-interacting protein 2 | Authors: | Strong, L.M, Flower, T.G, Buffalo, C.Z, Hurley, J.H. | Deposit date: | 2021-05-14 | Release date: | 2021-05-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy. Elife, 10, 2021
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7MGE
| Structure of C9orf72:SMCR8:WDR41 in complex with ARF1 | Descriptor: | ADP-ribosylation factor 1, BERYLLIUM TRIFLUORIDE ION, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Su, M.-Y, Hurley, J.H. | Deposit date: | 2021-04-12 | Release date: | 2021-06-23 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.94 Å) | Cite: | Structural basis for the ARF GAP activity and specificity of the C9orf72 complex. Nat Commun, 12, 2021
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6D83
| Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Buffalo, C.Z, Morris, K.L, Hurley, J.H. | Deposit date: | 2018-04-25 | Release date: | 2018-08-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.27 Å) | Cite: | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell, 174, 2018
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2PJW
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3TOW
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4R7X
| Crystal structure of N-lobe of human ARRDC3(1-180) | Descriptor: | Arrestin domain-containing protein 3, PHOSPHATE ION | Authors: | Qi, S, Hurley, J. | Deposit date: | 2014-08-28 | Release date: | 2014-10-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Insights into beta 2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci., 23, 2014
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4R7V
| Crystal structure of N-lobe of human ARRDC3(1-165) | Descriptor: | Arrestin domain-containing protein 3 | Authors: | Qi, S, Hurley, J. | Deposit date: | 2014-08-28 | Release date: | 2014-10-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Insights into beta 2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3. Protein Sci., 23, 2014
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5C50
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9C82
| Structure of human ULK1C:PI3KC3-C1 supercomplex | Descriptor: | Beclin 1-associated autophagy-related key regulator, Beclin-1, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... | Authors: | Chen, M, Hurley, J.H. | Deposit date: | 2024-06-11 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (6.84 Å) | Cite: | Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex bioRxiv, 2023
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2ZME
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7UXH
| cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Cui, Z, Hurley, J. | Deposit date: | 2022-05-05 | Release date: | 2022-11-30 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
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7UX2
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7UXC
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6NZD
| Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) | Descriptor: | 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, Folliculin, Folliculin-interacting protein 2, ... | Authors: | Fromm, S.A, Young, L.N, Hurley, J.H. | Deposit date: | 2019-02-13 | Release date: | 2019-11-06 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex. Science, 366, 2019
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2R17
| Functional architecture of the retromer cargo-recognition complex | Descriptor: | GLYCEROL, Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | Authors: | Hierro, A, Rojas, A.L, Rojas, R, Murthy, N, Effantin, G, Kajava, A.V, Steven, A.C, Bonifacino, J.S, Hurley, J.H. | Deposit date: | 2007-08-22 | Release date: | 2007-10-30 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Functional architecture of the retromer cargo-recognition complex. Nature, 449, 2007
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7UX3
| Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes | Descriptor: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | Authors: | Hooy, R.M, Hurley, J.H. | Deposit date: | 2022-05-04 | Release date: | 2023-05-10 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (9.6 Å) | Cite: | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat. Sci Adv, 8, 2022
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1AB8
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6PAS
| Inactive State of Manduca sexta soluble guanylate cyclase | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | Authors: | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | Deposit date: | 2019-06-11 | Release date: | 2019-10-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. Elife, 8, 2019
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6PAT
| Active State of Manduca sexta soluble Guanylate Cyclase | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | Authors: | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | Deposit date: | 2019-06-11 | Release date: | 2019-10-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. Elife, 8, 2019
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3G9H
| Crystal structure of the C-terminal mu homology domain of Syp1 | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Suppressor of yeast profilin deletion | Authors: | Reider, A, Barker, S, Mishra, S, Im, Y.J, Maldonado-Baez, L, Hurley, J, Traub, L, Wendland, B. | Deposit date: | 2009-02-13 | Release date: | 2009-09-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. Embo J., 28, 2009
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6VME
| Human ESCRT-I heterotetramer headpiece | Descriptor: | Multivesicular body subunit 12A, Tumor susceptibility gene 101 protein, Vacuolar protein sorting-associated protein 28 homolog, ... | Authors: | Flower, T.G, Hurley, J.H, Tjahjono, N. | Deposit date: | 2020-01-27 | Release date: | 2020-05-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. Nat.Struct.Mol.Biol., 27, 2020
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6WCW
| Structure of human Rubicon RH domain in complex with GTP-bound Rab7 | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7a, ... | Authors: | Bhargava, H.K, Byck, J.M, Farrell, D.P, Anishchenko, I, DiMaio, F, Im, Y.J, Hurley, J.H. | Deposit date: | 2020-03-31 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex. Proc.Natl.Acad.Sci.USA, 117, 2020
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3G9G
| Crystal Structure of the N-terminal EFC/F-BAR domain of Syp1 | Descriptor: | Suppressor of yeast profilin deletion | Authors: | Reider, A, Barker, S, Mishra, S, Im, Y.J, Maldonado-Baez, L, Hurley, J, Traub, L, Wendland, B. | Deposit date: | 2009-02-13 | Release date: | 2009-09-22 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. Embo J., 28, 2009
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5L1Z
| TAR complex with HIV-1 Tat-AFF4-P-TEFb | Descriptor: | AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... | Authors: | Schulze-Gahmen, U, Hurley, J. | Deposit date: | 2016-07-29 | Release date: | 2016-10-26 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (5.9 Å) | Cite: | Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife, 5, 2016
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6OWT
| Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex | Descriptor: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit sigma, ... | Authors: | Buffalo, C.Z, Ren, X, Hurley, J.H. | Deposit date: | 2019-05-10 | Release date: | 2019-09-25 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission. Cell Host Microbe, 26, 2019
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