7MU2
 
 | | Crystal Structure of WIPI2 in complex with W2IR of ATG16L1 | | 分子名称: | Autophagy-related protein 16-1, WD repeat domain phosphoinositide-interacting protein 2 | | 著者 | Strong, L.M, Flower, T.G, Buffalo, C.Z, Hurley, J.H. | | 登録日 | 2021-05-14 | | 公開日 | 2021-05-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy.
Elife, 10, 2021
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7MGE
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6D83
 | | Structure of the cargo bound AP-1:Arf1:tetherin-Nef (L164A, L165A) dileucine mutant dimer monomeric subunit | | 分子名称: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | 著者 | Buffalo, C.Z, Morris, K.L, Hurley, J.H. | | 登録日 | 2018-04-25 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.27 Å) | | 主引用文献 | HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.
Cell, 174, 2018
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2PJW
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3TOW
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4R7X
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4R7V
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5C50
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9C82
 | | Structure of human ULK1C:PI3KC3-C1 supercomplex | | 分子名称: | Beclin 1-associated autophagy-related key regulator, Beclin-1, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... | | 著者 | Chen, M, Hurley, J.H. | | 登録日 | 2024-06-11 | | 公開日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | | 主引用文献 | Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
bioRxiv, 2023
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2ZME
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7UXH
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7UX2
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7UXC
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6NZD
 | | Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) | | 分子名称: | 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(thiophosphonooxy)phosphoryl]oxy}phosphoryl]-alpha-L-arabinofuranosyl}-3,9-dihydro-1H-purine-2,6-dione, Folliculin, Folliculin-interacting protein 2, ... | | 著者 | Fromm, S.A, Young, L.N, Hurley, J.H. | | 登録日 | 2019-02-13 | | 公開日 | 2019-11-06 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
Science, 366, 2019
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2R17
 | | Functional architecture of the retromer cargo-recognition complex | | 分子名称: | GLYCEROL, Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | | 著者 | Hierro, A, Rojas, A.L, Rojas, R, Murthy, N, Effantin, G, Kajava, A.V, Steven, A.C, Bonifacino, J.S, Hurley, J.H. | | 登録日 | 2007-08-22 | | 公開日 | 2007-10-30 | | 最終更新日 | 2017-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Functional architecture of the retromer cargo-recognition complex.
Nature, 449, 2007
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7UX3
 | | Asymmetric unit of AP-1, Arf1, Nef lattice on MHC-I lipopeptide incorporated narrow membrane tubes | | 分子名称: | ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ... | | 著者 | Hooy, R.M, Hurley, J.H. | | 登録日 | 2022-05-04 | | 公開日 | 2023-05-10 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (9.6 Å) | | 主引用文献 | Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
Sci Adv, 8, 2022
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1AB8
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6PAS
 | | Inactive State of Manduca sexta soluble guanylate cyclase | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | | 著者 | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | | 登録日 | 2019-06-11 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.
Elife, 8, 2019
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6PAT
 | | Active State of Manduca sexta soluble Guanylate Cyclase | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Soluble guanylyl cyclase alpha-1 subunit, Soluble guanylyl cyclase beta-1 subunit | | 著者 | Yokom, A.L, Horst, B.G, Marletta, M.A, Hurley, J.H. | | 登録日 | 2019-06-11 | | 公開日 | 2019-10-23 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | | 主引用文献 | Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.
Elife, 8, 2019
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3G9H
 | | Crystal structure of the C-terminal mu homology domain of Syp1 | | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Suppressor of yeast profilin deletion | | 著者 | Reider, A, Barker, S, Mishra, S, Im, Y.J, Maldonado-Baez, L, Hurley, J, Traub, L, Wendland, B. | | 登録日 | 2009-02-13 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation.
Embo J., 28, 2009
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6VME
 | | Human ESCRT-I heterotetramer headpiece | | 分子名称: | Multivesicular body subunit 12A, Tumor susceptibility gene 101 protein, Vacuolar protein sorting-associated protein 28 homolog, ... | | 著者 | Flower, T.G, Hurley, J.H, Tjahjono, N. | | 登録日 | 2020-01-27 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | | 主引用文献 | A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.
Nat.Struct.Mol.Biol., 27, 2020
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6WCW
 | | Structure of human Rubicon RH domain in complex with GTP-bound Rab7 | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7a, ... | | 著者 | Bhargava, H.K, Byck, J.M, Farrell, D.P, Anishchenko, I, DiMaio, F, Im, Y.J, Hurley, J.H. | | 登録日 | 2020-03-31 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.
Proc.Natl.Acad.Sci.USA, 117, 2020
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3G9G
 | | Crystal Structure of the N-terminal EFC/F-BAR domain of Syp1 | | 分子名称: | Suppressor of yeast profilin deletion | | 著者 | Reider, A, Barker, S, Mishra, S, Im, Y.J, Maldonado-Baez, L, Hurley, J, Traub, L, Wendland, B. | | 登録日 | 2009-02-13 | | 公開日 | 2009-09-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation.
Embo J., 28, 2009
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5L1Z
 | | TAR complex with HIV-1 Tat-AFF4-P-TEFb | | 分子名称: | AF4/FMR2 family member 4, Cyclin-T1, Cyclin-dependent kinase 9, ... | | 著者 | Schulze-Gahmen, U, Hurley, J. | | 登録日 | 2016-07-29 | | 公開日 | 2016-10-26 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (5.9 Å) | | 主引用文献 | Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.
Elife, 5, 2016
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6OWT
 | | Structure of SIVsmm Nef and SMM tetherin bound to the clathrin adaptor AP-2 complex | | 分子名称: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit sigma, ... | | 著者 | Buffalo, C.Z, Ren, X, Hurley, J.H. | | 登録日 | 2019-05-10 | | 公開日 | 2019-09-25 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.
Cell Host Microbe, 26, 2019
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