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PDB: 46 results
2IEP
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BU of 2iep by Molmil
Crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK
Descriptor: Muscle-specific kinase receptor, SULFATE ION
Authors:Stiegler, A.L, Burden, S.J, Hubbard, S.R.
Deposit date:2006-09-19
Release date:2006-11-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Crystal Structure of the Agrin-responsive Immunoglobulin-like Domains 1 and 2 of the Receptor Tyrosine Kinase MuSK
J.Mol.Biol., 364, 2006
2HDV
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BU of 2hdv by Molmil
Crystal structure of the Src Homology-2 domain of the adapter protein SH2-B
Descriptor: SH2-B PH domain containing signaling mediator 1 gamma isoform
Authors:Hu, J, Hubbard, S.R.
Deposit date:2006-06-20
Release date:2006-08-08
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2HDX
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BU of 2hdx by Molmil
Crystal structure of the Src homology-2 domain of SH2-B in complex with Jak2 pTyr813 phosphopeptide
Descriptor: Jak2 protein, SH2-B PH domain containing signaling mediator 1 gamma isoform
Authors:Hu, J, Hubbard, S.R.
Deposit date:2006-06-21
Release date:2006-08-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Phosphotyrosine Recognition by the Src Homology-2 Domains of the Adapter Proteins SH2-B and APS.
J.Mol.Biol., 361, 2006
2HMH
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BU of 2hmh by Molmil
Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.
Descriptor: Interleukin-6 receptor beta chain, Suppressor of cytokine signaling 3
Authors:Bergamin, E, Wu, J, Hubbard, S.R.
Deposit date:2006-07-11
Release date:2006-08-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.
Structure, 14, 2006
1GAG
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BU of 1gag by Molmil
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Descriptor: BISUBSTRATE PEPTIDE INHIBITOR, INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, ...
Authors:Parang, K, Till, J.H, Ablooglu, A.J, Kohanski, R.A, Hubbard, S.R, Cole, P.A.
Deposit date:2000-11-29
Release date:2001-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001
1FGI
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BU of 1fgi by Molmil
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Descriptor: 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE, FGF RECEPTOR 1
Authors:Mohammadi, M, Schlessinger, J, Hubbard, S.R.
Deposit date:1997-03-22
Release date:1998-04-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
4FVP
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BU of 4fvp by Molmil
Crystal structure of the Jak2 pseudokinase domain (apo form)
Descriptor: GLYCEROL, Tyrosine-protein kinase JAK2
Authors:Bandaranayake, R.M, Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
4FVR
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BU of 4fvr by Molmil
Crystal structure of the Jak2 pseudokinase domain mutant V617F (Mg-ATP-bound form)
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tyrosine-protein kinase JAK2
Authors:Bandaranayake, R.M, Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
4FVQ
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BU of 4fvq by Molmil
Crystal structure of the Jak2 pseudokinase domain (Mg-ATP-bound form)
Descriptor: ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bandaranayake, R.M, Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
1EV2
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BU of 1ev2 by Molmil
CRYSTAL STRUCTURE OF FGF2 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 2 (FGFR2)
Descriptor: PROTEIN (FIBROBLAST GROWTH FACTOR 2), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 2), SULFATE ION
Authors:Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M.
Deposit date:2000-04-19
Release date:2000-05-31
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1EVT
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BU of 1evt by Molmil
CRYSTAL STRUCTURE OF FGF1 IN COMPLEX WITH THE EXTRACELLULAR LIGAND BINDING DOMAIN OF FGF RECEPTOR 1 (FGFR1)
Descriptor: PROTEIN (FIBROBLAST GROWTH FACTOR 1), PROTEIN (FIBROBLAST GROWTH FACTOR RECEPTOR 1), SULFATE ION
Authors:Plotnikov, A.N, Hubbard, S.R, Schlessinger, J, Mohammadi, M.
Deposit date:2000-04-20
Release date:2000-05-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity.
Cell(Cambridge,Mass.), 101, 2000
1P14
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BU of 1p14 by Molmil
Crystal structure of a catalytic-loop mutant of the insulin receptor tyrosine kinase
Descriptor: insulin receptor
Authors:Li, S, Covino, N.D, Stein, E.G, Till, J.H, Hubbard, S.R.
Deposit date:2003-04-11
Release date:2003-07-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor
J.Biol.Chem., 278, 2003
1NRV
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BU of 1nrv by Molmil
Crystal structure of the SH2 domain of Grb10
Descriptor: Growth factor receptor-bound protein 10
Authors:Stein, E.G, Hubbard, S.R.
Deposit date:2003-01-25
Release date:2003-04-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
J.Biol.Chem., 278, 2003
1FGK
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BU of 1fgk by Molmil
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1
Descriptor: FGF RECEPTOR 1
Authors:Mohammadi, M, Schlessinger, J, Hubbard, S.R.
Deposit date:1997-02-08
Release date:1997-07-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
Cell(Cambridge,Mass.), 86, 1996
1RQQ
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BU of 1rqq by Molmil
Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
Descriptor: BISUBSTRATE INHIBITOR, Insulin receptor, MANGANESE (II) ION, ...
Authors:Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R.
Deposit date:2003-12-06
Release date:2003-12-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
1I44
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BU of 1i44 by Molmil
CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor: INSULIN RECEPTOR, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Till, J.H, Ablooglu, A.J, Frankel, M, Kohanski, R.A, Hubbard, S.R.
Deposit date:2001-02-19
Release date:2001-03-07
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
J.Biol.Chem., 276, 2001
1RPY
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BU of 1rpy by Molmil
CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS
Descriptor: SULFATE ION, adaptor protein APS
Authors:Hu, J, Liu, J, Ghirlando, R, Saltiel, A.R, Hubbard, S.R.
Deposit date:2003-12-03
Release date:2003-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Mol.Cell, 12, 2003
3BCH
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BU of 3bch by Molmil
Crystal Structure of the Human Laminin Receptor Precursor
Descriptor: 40S ribosomal protein SA
Authors:Jamieson, K.V, Wu, J, Hubbard, S.R, Meruelo, D.
Deposit date:2007-11-12
Release date:2007-12-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the human laminin receptor precursor.
J.Biol.Chem., 283, 2008
3BU5
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BU of 3bu5 by Molmil
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Insulin receptor substrate 2, MAGNESIUM ION, ...
Authors:Wu, J, Hubbard, S.R.
Deposit date:2007-12-31
Release date:2008-02-19
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Nat.Struct.Mol.Biol., 15, 2008
3BU3
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BU of 3bu3 by Molmil
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide
Descriptor: Insulin receptor substrate 2, insulin receptor subunit beta
Authors:Wu, J, Hubbard, S.R.
Deposit date:2007-12-31
Release date:2008-02-19
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Nat.Struct.Mol.Biol., 15, 2008
3BU6
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BU of 3bu6 by Molmil
Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB phosphopeptide
Descriptor: Insulin receptor substrate 2, insulin receptor subunit beta
Authors:Wu, J, Hubbard, S.R.
Deposit date:2007-12-31
Release date:2008-02-19
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
Nat.Struct.Mol.Biol., 15, 2008
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