1GAG

CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR

Summary for 1GAG

• Entry DOI: 10.2210/pdb1gag/pdb
• Related: 1IR3
• Descriptor: INSULIN RECEPTOR, TYROSINE KINASE DOMAIN, BISUBSTRATE PEPTIDE INHIBITOR, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: protein kinase inhibitor, tyrosine kinase, transferase, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P06213
• Total number of polymer chains: 2
• Total formula weight: 36985.14

Authors

Parang, K.,Till, J.H.,Ablooglu, A.J.,Kohanski, R.A.,Hubbard, S.R.,Cole, P.A. (deposition date: 2000-11-29, release date: 2001-01-17, Last modification date: 2023-11-15)

• Primary citation: Parang, K.,Till, J.H.,Ablooglu, A.J.,Kohanski, R.A.,Hubbard, S.R.,Cole, P.A.; Mechanism-based design of a protein kinase inhibitor.; Nat.Struct.Biol., 8:37-41, 2001; PubMed: 11135668; DOI: 10.1038/83028

Experimental method

X-RAY DIFFRACTION (2.7 Å)