Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0004714 | molecular_function | transmembrane receptor protein tyrosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007169 | biological_process | cell surface receptor protein tyrosine kinase signaling pathway |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 201 |
| Chain | Residue |
| A | ASN1137 |
| A | ASP1150 |
| B | HOH1 |
| B | 112101 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 202 |
| Chain | Residue |
| A | HOH21 |
| A | HOH22 |
| A | ASP1150 |
| B | HOH20 |
| B | 112101 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 112 B 101 |
| Chain | Residue |
| A | MG201 |
| A | MG202 |
| A | LEU1002 |
| A | GLY1005 |
| A | SER1006 |
| A | VAL1010 |
| A | ALA1028 |
| A | LYS1030 |
| A | GLU1077 |
| A | MET1079 |
| A | ASP1083 |
| A | ASP1132 |
| A | ARG1136 |
| A | ASN1137 |
| A | ASP1150 |
| B | HOH1 |
| B | HOH14 |
| B | HOH20 |
| B | PRO102 |
| B | ALA103 |
| B | PHE107 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR CHAIN B OF BISUBSTRATE PEPTIDE INHIBITOR |
| Chain | Residue |
| A | GLN1004 |
| A | GLU1094 |
| A | ARG1136 |
| A | GLY1167 |
| A | LYS1168 |
| A | GLY1169 |
| A | LEU1170 |
| A | LEU1171 |
| A | PRO1172 |
| A | VAL1173 |
| A | TRP1175 |
| A | LEU1181 |
| A | LYS1182 |
| A | ASP1183 |
| A | GLY1184 |
| A | ASN1215 |
| A | ASP1232 |
| B | HOH6 |
| B | 112101 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 29 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGSFGMVYeGnardiikgeaetr.....VAVK |
| Chain | Residue | Details |
| A | LEU1002-LYS1030 | |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCMV |
| Chain | Residue | Details |
| A | PHE1128-VAL1140 | |
| site_id | PS00239 |
| Number of Residues | 9 |
| Details | RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. DIYetdYYR |
| Chain | Residue | Details |
| A | ASP1156-ARG1164 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ASP1132 | |
| Chain | Residue | Details |
| A | SER1006 | |
| A | LYS1030 | |
| A | GLU1077 | |
| A | ARG1136 | |
| A | ASP1150 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305 |
| Chain | Residue | Details |
| A | PHE984 | |
| Chain | Residue | Details |
| A | CYS1056 | |
| Chain | Residue | Details |
| A | PTR1158 | |
| A | PTR1162 | |
| A | PTR1163 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP1132 | |
| A | ARG1136 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP1132 | |
| A | ALA1134 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP1132 | |
| A | ASN1137 | |
| A | ALA1134 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 246 |
| Chain | Residue | Details |
| A | ASP1132 | increase nucleophilicity, proton acceptor, proton donor, steric role |
| A | ARG1136 | electrostatic stabiliser, increase electrophilicity, promote heterolysis |
| A | ASN1137 | metal ligand |
| A | ASP1150 | metal ligand |
