1GAG
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | INSULIN RECEPTOR, TYROSINE KINASE DOMAIN | polymer | 306 | 35032.7 | 1 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (human) | IR |
| 2 | B (B) | BISUBSTRATE PEPTIDE INHIBITOR | polymer | 13 | 1323.5 | 1 | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (B) | THIOPHOSPHORIC ACID O-((ADENOSYL-PHOSPHO)PHOSPHO)-S-ACETAMIDYL-DIESTER | non-polymer | 580.3 | 1 | Chemie (112) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 978 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Ser 981 | Cys 1008 | engineered mutation |
| Phe 984 | Tyr 1011 | engineered mutation |
| Ptr 1158 | Tyr 1185 | modified residue |
| Ptr 1162 | Tyr 1189 | modified residue |
| Ptr 1162 | Tyr 1190 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36356.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 628.9 | |
| All* | Total formula weight | 36985.1 |
