1RQQ

Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS

Summary for 1RQQ

• Entry DOI: 10.2210/pdb1rqq/pdb
• Descriptor: Insulin receptor, adaptor protein APS, BISUBSTRATE INHIBITOR, ... (6 entities in total)
• Functional Keywords: protein tyrosine kinase, adaptor protein, sh2 domain, transferase-signaling protein complex, transferase/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P06213; Cytoplasm: Q9Z200
• Total number of polymer chains: 6
• Total formula weight: 100999.71

Authors

Hu, J.,Liu, J.,Ghirlando, R.,Saltiel, A.R.,Hubbard, S.R. (deposition date: 2003-12-06, release date: 2003-12-30, Last modification date: 2023-11-15)

• Primary citation: Hu, J.,Liu, J.,Ghirlando, R.,Saltiel, A.R.,Hubbard, S.R.; Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.; Mol.Cell, 12:1379-1389, 2003; PubMed: 14690593; DOI: 10.1016/S1097-2765(03)00487-8

Experimental method

X-RAY DIFFRACTION (2.6 Å)