4FVP
Crystal structure of the Jak2 pseudokinase domain (apo form)
Summary for 4FVP
| Entry DOI | 10.2210/pdb4fvp/pdb |
| Related | 4FVQ 4FVR |
| Descriptor | Tyrosine-protein kinase JAK2, GLYCEROL (3 entities in total) |
| Functional Keywords | janus protein kinase, pseudokinase, atp binding, phosphorylation, transferase |
| Biological source | Homo sapiens (human) |
| Cellular location | Endomembrane system; Peripheral membrane protein (By similarity): O60674 |
| Total number of polymer chains | 1 |
| Total formula weight | 33305.15 |
| Authors | Bandaranayake, R.M.,Hubbard, S.R. (deposition date: 2012-06-29, release date: 2012-07-25, Last modification date: 2023-09-13) |
| Primary citation | Bandaranayake, R.M.,Ungureanu, D.,Shan, Y.,Shaw, D.E.,Silvennoinen, O.,Hubbard, S.R. Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. Nat.Struct.Mol.Biol., 19:754-759, 2012 Cited by PubMed: 22820988DOI: 10.1038/nsmb.2348 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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