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4FVP

Crystal structure of the Jak2 pseudokinase domain (apo form)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 901
ChainResidue
ASER605
AHIS606
ALYS607
ALEU609
ALYS696
AHOH1001

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 902
ChainResidue
ATRP718
AHOH1007
AHOH1125
AHOH1149
AASN673
ACYS675
AARG715

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Breakpoint for translocation to form PCM1-JAK2 fusion protein
ChainResidueDetails
AASP710

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR570

227111

PDB entries from 2024-11-06

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