3BU6

Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB phosphopeptide

Summary for 3BU6

Entry DOI	10.2210/pdb3bu6/pdb
Related	3BU3 3BU5
Descriptor	insulin receptor subunit beta, Insulin receptor substrate 2 (3 entities in total)
Functional Keywords	ir, irk, irs-2, krlb, insulin receptor, phosphopeptide, alternative splicing, atp-binding, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, polymorphism, transferase, transmembrane, tyrosine-protein kinase, transducer
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Single-pass type I membrane protein: P06213 Cytoplasm, cytosol: P81122
Total number of polymer chains	2
Total formula weight	36829.41
Authors	Wu, J.,Hubbard, S.R. (deposition date: 2007-12-31, release date: 2008-02-19, Last modification date: 2021-10-20)
Primary citation	Wu, J.,Tseng, Y.D.,Xu, C.F.,Neubert, T.A.,White, M.F.,Hubbard, S.R. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat.Struct.Mol.Biol., 15:251-258, 2008 Cited by PubMed: 18278056 DOI: 10.1038/nsmb.1388 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation