7V3A
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![BU of 7v3a by Molmil](/molmil-images/mine/7v3a) | Crystal structure of apo-NP exonuclease C409A | Descriptor: | MAGNESIUM ION, Nucleoprotein, ZINC ION | Authors: | Hsiao, Y.Y, Huang, K.W. | Deposit date: | 2021-08-10 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites. Jacs Au, 1, 2021
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7V38
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![BU of 7v38 by Molmil](/molmil-images/mine/7v38) | Crystal structure of NP exonuclease-PCMPS complex | Descriptor: | Nucleoprotein, PARA-MERCURY-BENZENESULFONIC ACID, ZINC ION | Authors: | Hsiao, Y.Y, Huang, K.W. | Deposit date: | 2021-08-10 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites. Jacs Au, 1, 2021
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7V3C
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![BU of 7v3c by Molmil](/molmil-images/mine/7v3c) | Crystal structure of NP exonuclease C409A-PCMB complex | Descriptor: | 4-(HYDROXYMERCURY)BENZOIC ACID, MAGNESIUM ION, Nucleoprotein, ... | Authors: | Hsiao, Y.Y, Huang, K.W. | Deposit date: | 2021-08-10 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites. Jacs Au, 1, 2021
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7V37
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![BU of 7v37 by Molmil](/molmil-images/mine/7v37) | Crystal structure of apo-NP exonuclease | Descriptor: | Nucleoprotein, ZINC ION | Authors: | Hsiao, Y.Y, Huang, K.W. | Deposit date: | 2021-08-10 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites. Jacs Au, 1, 2021
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7V3B
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![BU of 7v3b by Molmil](/molmil-images/mine/7v3b) | Crystal structure of NP exonuclease C409A-PCMPS complex | Descriptor: | MAGNESIUM ION, Nucleoprotein, PARA-MERCURY-BENZENESULFONIC ACID, ... | Authors: | Hsiao, Y.Y, Huang, K.W. | Deposit date: | 2021-08-10 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites. Jacs Au, 1, 2021
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7V39
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![BU of 7v39 by Molmil](/molmil-images/mine/7v39) | Crystal structure of NP exonuclease-PCMB complex | Descriptor: | 4-(HYDROXYMERCURY)BENZOIC ACID, Nucleoprotein, ZINC ION | Authors: | Hsiao, Y.Y, Huang, K.W. | Deposit date: | 2021-08-10 | Release date: | 2021-12-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites. Jacs Au, 1, 2021
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5E2J
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![BU of 5e2j by Molmil](/molmil-images/mine/5e2j) | Crystal structure of single mutant thermostable endoglucanase (D468A) from Alicyclobacillus acidocaldarius | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, Endoglucanase, ... | Authors: | Hsiao, Y.Y, Wang, H.J, Tseng, C.P. | Deposit date: | 2015-10-01 | Release date: | 2016-02-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Polarity Alteration of a Calcium Site Induces a Hydrophobic Interaction Network and Enhances Cel9A Endoglucanase Thermostability. Appl.Environ.Microbiol., 82, 2016
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8HCG
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![BU of 8hcg by Molmil](/molmil-images/mine/8hcg) | Crystal structure of mTREX1-dAMP complex | Descriptor: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.799 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCD
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![BU of 8hcd by Molmil](/molmil-images/mine/8hcd) | Crystal structure of mTREX1-DNA product complex (dNMP) | Descriptor: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, COBALT (II) ION, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCE
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![BU of 8hce by Molmil](/molmil-images/mine/8hce) | Crystal structure of mTREX1-CMP complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AMMONIUM ION, CYTIDINE-5'-MONOPHOSPHATE, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCF
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![BU of 8hcf by Molmil](/molmil-images/mine/8hcf) | Crystal structure of mTREX1-UMP complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, Three-prime repair exonuclease 1, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCC
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![BU of 8hcc by Molmil](/molmil-images/mine/8hcc) | Crystal structure of mTREX1-RNA product complex (AMP) | Descriptor: | ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, SODIUM ION, ... | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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8HCH
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![BU of 8hch by Molmil](/molmil-images/mine/8hch) | Crystal structure of mTREX1-Uridine complex | Descriptor: | MAGNESIUM ION, Three-prime repair exonuclease 1, URIDINE | Authors: | Hsiao, Y.Y, Huang, K.W, Wu, C.Y. | Deposit date: | 2022-11-01 | Release date: | 2023-11-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51, 2023
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5YWV
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![BU of 5ywv by Molmil](/molmil-images/mine/5ywv) | |
5YWT
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![BU of 5ywt by Molmil](/molmil-images/mine/5ywt) | |
6A46
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![BU of 6a46 by Molmil](/molmil-images/mine/6a46) | Structure of TREX2 in complex with a nucleotide (dCMP) | Descriptor: | 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... | Authors: | Hsiao, Y.Y. | Deposit date: | 2018-06-19 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res., 46, 2018
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6A4B
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![BU of 6a4b by Molmil](/molmil-images/mine/6a4b) | |
6A47
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![BU of 6a47 by Molmil](/molmil-images/mine/6a47) | Structure of TREX2 in complex with a Y structured dsDNA | Descriptor: | DNA (5'-D(P*CP*CP*AP*GP*GP*CP*CP*CP*TP*CP*TP*AP*GP*GP*GP*CP*CP*TP*T)-3'), MAGNESIUM ION, SODIUM ION, ... | Authors: | Hsiao, Y.Y. | Deposit date: | 2018-06-19 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res., 46, 2018
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6A45
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![BU of 6a45 by Molmil](/molmil-images/mine/6a45) | Structure of mouse TREX2 | Descriptor: | PHOSPHATE ION, Three prime repair exonuclease 2 | Authors: | Hsiao, Y.Y. | Deposit date: | 2018-06-19 | Release date: | 2018-11-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.904 Å) | Cite: | Structural insights into the duplex DNA processing of TREX2 Nucleic Acids Res., 46, 2018
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5YWU
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![BU of 5ywu by Molmil](/molmil-images/mine/5ywu) | |
5YWS
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![BU of 5yws by Molmil](/molmil-images/mine/5yws) | Crystal structure of TREX1 in complex with a Y structured DNA | Descriptor: | A STEM LOOP DNA WITH Y-STRUCTURAL TERMINAL, MAGNESIUM ION, Three-prime repair exonuclease 1 | Authors: | Hsiao, Y.Y. | Deposit date: | 2017-11-30 | Release date: | 2018-05-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1 PLoS Biol., 16, 2018
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6KYC
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![BU of 6kyc by Molmil](/molmil-images/mine/6kyc) | Structure of the S207A mutant of Clostridium difficile sortase B | Descriptor: | Putative peptidase C60B, sortase B | Authors: | Kang, C.Y, Huang, I.H, Wu, T.Y, Chang, J.C, Hsiao, Y.Y, Cheng, C.H, Tsai, W.J, Hsu, K.C, Wang, S.Y. | Deposit date: | 2019-09-17 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Functional analysis ofClostridium difficilesortase B reveals key residues for catalytic activity and substrate specificity. J.Biol.Chem., 295, 2020
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6KYD
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![BU of 6kyd by Molmil](/molmil-images/mine/6kyd) | Structure of the R217A mutant of Clostridium difficile sortase B | Descriptor: | Putative peptidase C60B, sortase B | Authors: | Kang, C.Y, Huang, I.H, Wu, T.Y, Chang, J.C, Hsiao, Y.Y, Cheng, C.H, Tsai, W.J, Hsu, K.C, Wang, S.Y. | Deposit date: | 2019-09-18 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Functional analysis ofClostridium difficilesortase B reveals key residues for catalytic activity and substrate specificity. J.Biol.Chem., 295, 2020
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7CD6
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![BU of 7cd6 by Molmil](/molmil-images/mine/7cd6) | mAPE1-recessed dsDNA product complex | Descriptor: | DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*AP*C)-3'), DNA-(apurinic or apyrimidinic site) endonuclease | Authors: | Liu, T.C, Hsiao, Y.Y. | Deposit date: | 2020-06-18 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling. Nat Commun, 12, 2021
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7CD5
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![BU of 7cd5 by Molmil](/molmil-images/mine/7cd5) | mAPE1-blunt-ended dsDNA product complex | Descriptor: | DNA(5'-D(*CP*GP*TP*AP*AP*TP*AP*CP*G)-3'), DNA-(apurinic or apyrimidinic site) endonuclease | Authors: | Liu, T.C, Hsiao, Y.Y. | Deposit date: | 2020-06-18 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling. Nat Commun, 12, 2021
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