7V38

Crystal structure of NP exonuclease-PCMPS complex

Summary for 7V38

• Entry DOI: 10.2210/pdb7v38/pdb
• Related: 7V37
• Descriptor: Nucleoprotein, ZINC ION, PARA-MERCURY-BENZENESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: deddh exonuclease, np exonuclease, anti-viral drug, pcmps, pcmb, viral protein
• Biological source: Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)
• Total number of polymer chains: 2
• Total formula weight: 56233.61

Authors

Hsiao, Y.Y.,Huang, K.W. (deposition date: 2021-08-10, release date: 2021-12-15, Last modification date: 2023-11-29)

• Primary citation: Huang, K.W.,Chen, J.W.,Hua, T.Y.,Chu, Y.Y.,Chiu, T.Y.,Liu, J.Y.,Tu, C.I.,Hsu, K.C.,Kao, Y.T.,Chu, J.W.,Hsiao, Y.Y.; Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites.; Jacs Au, 1:2315-2327, 2021; PubMed: 34977900; DOI: 10.1021/jacsau.1c00420

Experimental method

X-RAY DIFFRACTION (2.403 Å)