7V39

Crystal structure of NP exonuclease-PCMB complex

Summary for 7V39

Entry DOI	10.2210/pdb7v39/pdb
Related	7V37 7V38
Descriptor	Nucleoprotein, ZINC ION, 4-(HYDROXYMERCURY)BENZOIC ACID, ... (4 entities in total)
Functional Keywords	deddh exonuclease, np exonuclease, anti-viral drug, pcmps, pcmb, viral protein
Biological source	Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV)
Total number of polymer chains	2
Total formula weight	56195.52
Authors	Hsiao, Y.Y.,Huang, K.W. (deposition date: 2021-08-10, release date: 2021-12-15, Last modification date: 2023-11-29)
Primary citation	Huang, K.W.,Chen, J.W.,Hua, T.Y.,Chu, Y.Y.,Chiu, T.Y.,Liu, J.Y.,Tu, C.I.,Hsu, K.C.,Kao, Y.T.,Chu, J.W.,Hsiao, Y.Y. Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites. Jacs Au, 1:2315-2327, 2021 Cited by PubMed: 34977900 DOI: 10.1021/jacsau.1c00420 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation