8HCF

Crystal structure of mTREX1-UMP complex

Summary for 8HCF

Entry DOI	10.2210/pdb8hcf/pdb
Related	8HCC 8HCD 8HCE
Descriptor	Three-prime repair exonuclease 1, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, ... (5 entities in total)
Functional Keywords	trex1, deddh exonuclease, dnase, rnase, ump, hydrolase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	55640.90
Authors	Hsiao, Y.Y.,Huang, K.W.,Wu, C.Y. (deposition date: 2022-11-01, release date: 2023-11-08, Last modification date: 2023-12-13)
Primary citation	Huang, K.W.,Wu, C.Y.,Toh, S.I.,Liu, T.C.,Tu, C.I.,Lin, Y.H.,Cheng, A.J.,Kao, Y.T.,Chu, J.W.,Hsiao, Y.Y. Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids. Nucleic Acids Res., 51:11927-11940, 2023 Cited by PubMed: 37870446 DOI: 10.1093/nar/gkad910 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation