3LGW
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3LGY
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![BU of 3lgy by Molmil](/molmil-images/mine/3lgy) | R178A mutant of the DegS-deltaPDZ protease | Descriptor: | CHLORIDE ION, MAGNESIUM ION, Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3O1F
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![BU of 3o1f by Molmil](/molmil-images/mine/3o1f) | P1 crystal form of E. coli ClpS at 1.4 A resolution | Descriptor: | ATP-dependent Clp protease adapter protein clpS | Authors: | Roman-Hernandez, G, Hou, J.Y, Grant, R.A, Sauer, R.T, Baker, T.A. | Deposit date: | 2010-07-21 | Release date: | 2011-07-27 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease. Mol.Cell, 43, 2011
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3HE5
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3HE4
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5W8F
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![BU of 5w8f by Molmil](/molmil-images/mine/5w8f) | Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14 | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-14 | Authors: | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | Deposit date: | 2017-06-21 | Release date: | 2018-01-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3KZ0
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![BU of 3kz0 by Molmil](/molmil-images/mine/3kz0) | MCL-1 complex with MCL-1-specific selected peptide | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 specific peptide MB7, SULFATE ION, ... | Authors: | Dutta, S, Fire, E, Grant, R.A, Sauer, R.T, Keating, A.E. | Deposit date: | 2009-12-07 | Release date: | 2010-05-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.349 Å) | Cite: | Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J.Mol.Biol., 398, 2010
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6CZF
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![BU of 6czf by Molmil](/molmil-images/mine/6czf) | The structure of E. coli PurF in complex with ppGpp-Mg | Descriptor: | Amidophosphoribosyltransferase, GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION | Authors: | Wang, B, Grant, R.A, Laub, M.T. | Deposit date: | 2018-04-09 | Release date: | 2018-10-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Affinity-based capture and identification of protein effectors of the growth regulator ppGpp. Nat. Chem. Biol., 15, 2019
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3KJ0
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![BU of 3kj0 by Molmil](/molmil-images/mine/3kj0) | Mcl-1 in complex with Bim BH3 mutant I2dY | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Fire, E, Grant, R.A, Keating, A.E. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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3KJ1
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![BU of 3kj1 by Molmil](/molmil-images/mine/3kj1) | Mcl-1 in complex with Bim BH3 mutant I2dA | Descriptor: | ACETATE ION, Bcl-2-like protein 11, CHLORIDE ION, ... | Authors: | Fire, E, Grant, R.A, Keating, A.E. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.945 Å) | Cite: | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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3KJ2
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![BU of 3kj2 by Molmil](/molmil-images/mine/3kj2) | Mcl-1 in complex with Bim BH3 mutant F4aE | Descriptor: | ACETATE ION, Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ... | Authors: | Fire, E, Grant, R.A, Keating, A.E. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.351 Å) | Cite: | Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci., 19, 2010
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5UUM
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![BU of 5uum by Molmil](/molmil-images/mine/5uum) | Human Mcl-1 in complex with a Bfl-1-specific selected peptide | Descriptor: | Bfl-1 specific peptide FS2, Induced myeloid leukemia cell differentiation protein Mcl-1, SULFATE ION, ... | Authors: | Jenson, J.M, Grant, R.A, Keating, A.E. | Deposit date: | 2017-02-17 | Release date: | 2017-06-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.346 Å) | Cite: | Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife, 6, 2017
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5UUP
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5UUL
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![BU of 5uul by Molmil](/molmil-images/mine/5uul) | Human Bfl-1 in complex with PUMA BH3 | Descriptor: | Bcl-2-binding component 3, Bcl-2-related protein A1, SULFATE ION | Authors: | Jenson, J.M, Grant, R.A, Keating, A.E. | Deposit date: | 2017-02-17 | Release date: | 2017-06-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.33 Å) | Cite: | Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife, 6, 2017
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5UUK
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5TXR
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![BU of 5txr by Molmil](/molmil-images/mine/5txr) | Structure of ALAS from S. cerevisiae non-covalently bound to PLP cofactor | Descriptor: | 5-aminolevulinate synthase, mitochondrial, FORMIC ACID, ... | Authors: | Brown, B.L, Grant, R.A, Kardon, J.R, Sauer, R.T, Baker, T.A. | Deposit date: | 2016-11-17 | Release date: | 2018-03-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme. Structure, 26, 2018
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5TXT
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![BU of 5txt by Molmil](/molmil-images/mine/5txt) | Structure of asymmetric apo/holo ALAS dimer from S. cerevisiae | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, 5-aminolevulinate synthase, mitochondrial, ... | Authors: | Brown, B.L, Grant, R.A, Kardon, J.R, Sauer, R.T, Baker, T.A. | Deposit date: | 2016-11-17 | Release date: | 2018-03-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of the Mitochondrial Aminolevulinic Acid Synthase, a Key Heme Biosynthetic Enzyme. Structure, 26, 2018
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