5UUM

Human Mcl-1 in complex with a Bfl-1-specific selected peptide

Summary for 5UUM

Entry DOI	10.2210/pdb5uum/pdb
Related	5UUK 5UUL 5UUP
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, Bfl-1 specific peptide FS2, ZINC ION, ... (5 entities in total)
Functional Keywords	apoptosis regulatory proteins, peptide library, protein binding, protein structure, proto-oncogene, specificity, bcl2a1, bcl2 related protein a1, peptide inhibitor, apoptosis
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	41665.83
Authors	Jenson, J.M.,Grant, R.A.,Keating, A.E. (deposition date: 2017-02-17, release date: 2017-06-21, Last modification date: 2023-10-04)
Primary citation	Jenson, J.M.,Ryan, J.A.,Grant, R.A.,Letai, A.,Keating, A.E. Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1. Elife, 6:-, 2017 Cited by PubMed: 28594323 DOI: 10.7554/eLife.25541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.346 Å)

Structure validation