5UUP

Human Bfl-1 covalently cross-linked to an electrophilic variant of a Bfl-1-specific selected peptide

Summary for 5UUP

• Entry DOI: 10.2210/pdb5uup/pdb
• Related: 5UUK 5UUL 5UUM
• Descriptor: Bcl-2-related protein A1, Bfl-1-specific selected peptide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: apoptosis regulatory proteins, electrophile, protein binding, protein structure, proto-oncogene, specificity, bcl2a1, bcl2 related protein a1, peptide inhibitor, apoptosis
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 20149.79

Authors

Jenson, J.M.,Grant, R.A.,Keating, A.E. (deposition date: 2017-02-17, release date: 2017-06-21, Last modification date: 2023-10-04)

• Primary citation: Jenson, J.M.,Ryan, J.A.,Grant, R.A.,Letai, A.,Keating, A.E.; Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.; Elife, 6:-, 2017; PubMed: 28594323; DOI: 10.7554/eLife.25541

Experimental method

X-RAY DIFFRACTION (1.726 Å)